{"id":"W1994397669","doi":"10.1111/joim.12191","title":"Clinical trials and late‐stage drug development for <scp>A</scp>lzheimer's disease: an appraisal from 1984 to 2014","year":2014,"lang":"en","type":"review","venue":"Journal of Internal Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":641,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Aging; Novo Nordisk Fonden; Swedish Brain Power","keywords":"Clinical trial; Medicine; Disease; Drug development; Intensive care medicine; Memantine; Donepezil; Drug; Dementia; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.04799703,0.001228613,0.005215554,0.006820937,0.0005621202,0.004592475,0.001866627,0.002712709,0.003663548],"category_scores_gemma":[0.1000518,0.0009422632,0.00708432,0.007304541,0.001802705,0.003756288,0.002182815,0.00359341,0.0005910179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009053612,"about_ca_system_score_gemma":0.01510468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00474266,"about_ca_topic_score_gemma":0.01000638,"domain_scores_codex":[0.9593385,0.01901261,0.01173496,0.001245639,0.008056711,0.0006116275],"domain_scores_gemma":[0.8597326,0.09678261,0.02207398,0.001598202,0.0183833,0.001429242],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001769365,0.00005205347,0.0005254789,0.4695938,0.004926101,0.0001130095,0.000445152,0.0004506204,0.0005731747,0.006385856,0.02289522,0.4922702],"study_design_scores_gemma":[0.001220106,0.001176493,0.003924205,0.6522114,0.01612383,0.0002928684,0.0002750962,0.0002623683,0.0006861706,0.003435515,0.3203069,0.00008502448],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001974718,0.9967278,0.0001546532,0.001789306,0.000321178,0.0001263732,0.0001212266,0.000006751555,0.00055513],"genre_scores_gemma":[0.006235666,0.9866813,0.001225378,0.004377327,0.000455371,0.0005034313,0.0001535657,0.00001381178,0.0003540249],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9520029,"threshold_uncertainty_score":0.2538356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.171360440473954,"score_gpt":0.5131438455241488,"score_spread":0.3417834050501948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}