{"id":"W1994412689","doi":"10.1126/science.1187107","title":"Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Canadian Food Inspection Agency","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse","keywords":"Chronic wasting disease; Prion protein; Gene isoform; Strain (injury); Genetically modified mouse; Biology; Nucleic acid; Transgene; Virology; Mutation; Scrapie; Genetics; Disease; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931583,0.0002124777,0.0001262865,0.0005310233,0.0001336356,0.0002603413,0.0001203542,0.0002194243,0.0006768496],"category_scores_gemma":[0.0004016102,0.0001197164,0.0001019591,0.0001723831,0.0003724555,0.0001465142,0.0002482033,0.0001997204,0.000225359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001367579,"about_ca_system_score_gemma":0.00009506027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003120783,"about_ca_topic_score_gemma":0.0003525917,"domain_scores_codex":[0.9998398,0.00002783533,0.00001949696,0.00004845553,0.00004403179,0.00002032646],"domain_scores_gemma":[0.9996836,0.00006786217,0.0001120686,0.00002480013,0.00004192957,0.00006977424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001945076,0.0000203085,0.01685745,0.00001889238,0.00001103493,0.000250959,0.00007427522,0.00001773755,0.9812188,0.0002054761,0.00001719515,0.001113423],"study_design_scores_gemma":[0.0000293262,0.0007406131,0.4208136,0.00002243991,0.00008799273,0.01071442,0.0002308344,0.0007529816,0.5644714,0.0004698155,0.001643689,0.00002270648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984621,0.0002656072,0.000462791,0.00001016363,0.000003006176,0.000009496977,0.00007912484,0.000005135229,0.0007025931],"genre_scores_gemma":[0.9987156,0.000206373,0.0006382191,0.00001265412,0.000003480498,0.0000054986,0.0001692251,0.000003060701,0.0002458498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006768496,"threshold_uncertainty_score":0.002264261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003395336360520709,"score_gpt":0.2343103040627467,"score_spread":0.2309149677022261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}