{"id":"W1994412689","doi":"10.1126/science.1187107","title":"Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Canadian Food Inspection Agency","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse","keywords":"Chronic wasting disease; Prion protein; Gene isoform; Strain (injury); Genetically modified mouse; Biology; Nucleic acid; Transgene; Virology; Mutation; Scrapie; Genetics; Disease; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003001304,0.00007557567,0.00005394808,0.00002510218,0.0001752906,0.00006670843,0.0001504989,0.00005923429,0.0000267254],"category_scores_gemma":[0.0001380515,0.0000677225,0.00001602629,0.00007903348,0.0002903728,0.00002767539,0.00007818938,0.00007835097,9.995082e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001043765,"about_ca_system_score_gemma":0.0001752881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005013937,"about_ca_topic_score_gemma":0.00001392739,"domain_scores_codex":[0.999276,0.00001753274,0.0001209415,0.0002493949,0.0001950586,0.0001410758],"domain_scores_gemma":[0.9995798,0.000004718458,0.00007192865,0.0001684728,0.00008171478,0.00009333112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001734645,0.00000850959,0.0009697013,0.00001548092,0.000001068013,1.844586e-7,0.00002889438,0.000002554243,0.9344207,0.00006628222,0.00001697253,0.06445229],"study_design_scores_gemma":[0.0004158673,0.0001232659,0.1090715,0.00001074887,0.000003572417,0.00001745747,0.00002554999,0.001026448,0.8850081,0.001036686,0.003082383,0.0001784223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984592,0.0002455701,0.0006857907,0.00008415574,0.00006141609,0.000316315,0.00008933537,0.00000882275,0.00004936945],"genre_scores_gemma":[0.9969442,0.00001256408,0.002704808,0.0001184941,0.00003685304,0.000008388092,0.0001552413,0.000003290231,0.00001613429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1081018,"threshold_uncertainty_score":0.2761643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003395336360520709,"score_gpt":0.2343103040627467,"score_spread":0.2309149677022261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}