{"id":"W1994472094","doi":"10.1016/j.ymgme.2011.08.015","title":"Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency","year":2011,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Japan Society for the Promotion of Science","keywords":"Citrullinemia; Metabolite; Urea cycle; Metabolomics; Knockout mouse; Biochemistry; Chemistry; Arginine; Hyperammonemia; Citric acid cycle; Metabolome; Metabolism; Leucine; Sucrose; Internal medicine; Biology; Amino acid; Chromatography; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361477,0.0007286136,0.0005446297,0.0008141192,0.0002728043,0.0003373064,0.0002247858,0.0004419313,0.001313521],"category_scores_gemma":[0.0001854111,0.0003296574,0.0002977742,0.0003431604,0.000466669,0.000288072,0.00024783,0.0006643814,0.0001700536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474064,"about_ca_system_score_gemma":0.0002167814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049011,"about_ca_topic_score_gemma":0.001470457,"domain_scores_codex":[0.9998277,0.00001512996,0.00001479561,0.00006469429,0.0000412097,0.00003642759],"domain_scores_gemma":[0.9997553,0.00002606679,0.00007888173,0.00001943908,0.00002017084,0.0001001851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001101171,0.0000205339,0.0006678763,0.00001978794,0.00001748581,0.0001226224,0.00001404553,0.00004920198,0.9973676,0.00003767949,0.00003182207,0.0005502027],"study_design_scores_gemma":[0.00005442019,0.0003871257,0.02715034,0.000007696931,0.000130535,0.00105254,0.0001053169,0.0009506517,0.9691556,0.0001715733,0.0008173273,0.00001689532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939726,0.0006150226,0.003142245,0.0001454088,0.00002559629,0.00001808429,0.001687558,0.00009292929,0.0003005246],"genre_scores_gemma":[0.9931381,0.000454871,0.002957928,0.00011869,0.000008043615,0.00004341372,0.001372648,0.0000771405,0.001828976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313521,"threshold_uncertainty_score":0.004394114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800996940146669,"score_gpt":0.2476146863191786,"score_spread":0.2296047169177119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}