{"id":"W1994485752","doi":"10.1172/jci35243","title":"Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Kinase; Phosphorylation; Biology; GSK-3; Molecular biology; Internal medicine; Endocrinology; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521519,0.0004442188,0.0002220602,0.0002840802,0.0001124153,0.0002372932,0.0001530457,0.0001619959,0.0008599808],"category_scores_gemma":[0.00008335539,0.0002354432,0.0002992606,0.0001439202,0.0002539687,0.0001221711,0.0002052445,0.0005133675,0.0004572475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280505,"about_ca_system_score_gemma":0.0002978122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009019356,"about_ca_topic_score_gemma":0.001901788,"domain_scores_codex":[0.9998713,0.00001465081,0.0000159804,0.00002818429,0.00003091937,0.00003902913],"domain_scores_gemma":[0.9998846,0.000006911543,0.00003677934,0.00001167514,0.000006172349,0.00005374019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001478195,0.00002267215,0.0001739899,0.00002665103,0.000002816555,0.00002718801,0.00001046043,0.00003729154,0.9989457,0.00002788427,0.00003164692,0.000545861],"study_design_scores_gemma":[0.0001190346,0.001050169,0.0194143,0.00002593816,0.0000229985,0.0002643775,0.00004375005,0.001109361,0.9758425,0.00007814455,0.00202063,0.00000864914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944405,0.001804659,0.001091778,0.00008146924,0.00003654,0.00003409624,0.0004549318,0.000136889,0.001919184],"genre_scores_gemma":[0.9944883,0.001090376,0.001442411,0.00006627272,0.00001782672,0.00004834441,0.0005324056,0.00002572415,0.002288419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009019356,"threshold_uncertainty_score":0.002876878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04803445705178283,"score_gpt":0.3060201871914819,"score_spread":0.2579857301396991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}