{"id":"W1994510935","doi":"10.1097/01.tp.0000250769.86623.a3","title":"Protection of Renal Ischemia Injury using Combination Gene Silencing of Complement 3 and Caspase 3 Genes","year":2006,"lang":"en","type":"article","venue":"Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"","keywords":"Gene silencing; Creatinine; Kidney; Small interfering RNA; Renal ischemia; Acute kidney injury; Transplantation; RNA interference; Blood urea nitrogen; Caspase 3; Medicine; Biology; Pharmacology; Apoptosis; Pathology; Ischemia; Reperfusion injury; Gene; Transfection; Programmed cell death; Internal medicine; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003342002,0.0006994291,0.0005663557,0.0004008298,0.0001635572,0.0003570784,0.0003293458,0.0004643491,0.001396382],"category_scores_gemma":[0.0001624381,0.0001774172,0.0005752945,0.0001982212,0.0003391218,0.0003282978,0.000235826,0.0007857202,0.0003211431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003753302,"about_ca_system_score_gemma":0.0004558816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003787829,"about_ca_topic_score_gemma":0.0005753653,"domain_scores_codex":[0.9997528,0.00002844163,0.00003040142,0.0000544826,0.0000785731,0.00005533525],"domain_scores_gemma":[0.9998388,0.00002133954,0.00005946199,0.00002125395,0.0000271138,0.00003199946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002050593,0.00006068944,0.00009530141,0.00007339285,0.00001743434,0.00002717481,0.00000905236,0.0001034649,0.9973475,0.00008905571,0.000064377,0.001907447],"study_design_scores_gemma":[0.00006404147,0.001157564,0.0009535892,0.000007431863,0.00006167906,0.0001992565,0.00001053981,0.00116675,0.9950365,0.00004603764,0.001288987,0.000007467243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749658,0.004311239,0.01747692,0.0002342538,0.0001154488,0.0001614341,0.0003216722,0.0003506726,0.002062562],"genre_scores_gemma":[0.986653,0.001872056,0.008613264,0.0001299368,0.0000311736,0.000184865,0.000376029,0.00004292875,0.002096689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001396382,"threshold_uncertainty_score":0.004671395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02284257999881516,"score_gpt":0.2584118444656097,"score_spread":0.2355692644667945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}