{"id":"W1994510935","doi":"10.1097/01.tp.0000250769.86623.a3","title":"Protection of Renal Ischemia Injury using Combination Gene Silencing of Complement 3 and Caspase 3 Genes","year":2006,"lang":"en","type":"article","venue":"Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"","keywords":"Gene silencing; Creatinine; Kidney; Small interfering RNA; Renal ischemia; Acute kidney injury; Transplantation; RNA interference; Blood urea nitrogen; Caspase 3; Medicine; Biology; Pharmacology; Apoptosis; Pathology; Ischemia; Reperfusion injury; Gene; Transfection; Programmed cell death; Internal medicine; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104526,0.00007219333,0.0001285916,0.00009222017,0.00006062355,0.000002596222,0.0000322608,0.00004291053,0.00006305213],"category_scores_gemma":[0.000002316041,0.00007455439,0.00002587819,0.00006383895,0.00004961959,0.00006420964,0.00000596393,0.00003144037,0.000001275897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000226171,"about_ca_system_score_gemma":0.00001939889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001243453,"about_ca_topic_score_gemma":0.00007009144,"domain_scores_codex":[0.9993681,0.00007945577,0.000317805,0.0001104171,0.00004059354,0.00008359602],"domain_scores_gemma":[0.9996487,0.00002627317,0.0001874092,0.0000673603,0.00006477007,0.000005409049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001913069,0.00006728367,0.005650642,0.0002836964,0.00002920803,5.884515e-7,0.0002255449,0.0002220988,0.9924244,0.0002710903,0.00001522223,0.0006189337],"study_design_scores_gemma":[0.001316365,0.0001033011,0.02655914,0.0001055593,0.0001007971,0.00002241605,0.00008072962,0.0002324549,0.9713021,0.00009731897,0.00001379953,0.00006600883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893019,0.0004384026,0.00962639,0.00001000147,0.00007499548,0.0003295625,0.0001733565,0.00001514586,0.00003019694],"genre_scores_gemma":[0.9993266,0.00002211115,0.0002437154,0.000002071379,0.00001022024,0.00001333874,0.0003658612,0.00000522387,0.00001087686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02112227,"threshold_uncertainty_score":0.304024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02284257999881516,"score_gpt":0.2584118444656097,"score_spread":0.2355692644667945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}