{"id":"W1994512364","doi":"10.1016/j.yexcr.2007.06.027","title":"15-Deoxy-Δ12,14-prostaglandin J2 down-regulates CXCR4 on carcinoma cells through PPARγ- and NFκB-mediated pathways","year":2007,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts; National Institutes of Health; Nova Scotia Health Research Foundation","keywords":"Biology; Nuclear receptor; CXCR4; Context (archaeology); Agonist; Cancer research; Receptor; Chemokine; Chemokine receptor; Prostaglandin D2; Prostaglandin E; Prostaglandin; Cell biology; Internal medicine; Endocrinology; Biochemistry; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001794871,0.0003649115,0.0003158197,0.0004558629,0.0003482621,0.0004385133,0.0001867439,0.0002357597,0.003099474],"category_scores_gemma":[0.0001383403,0.0002047131,0.0004225669,0.0003119745,0.0002649854,0.0002491375,0.0001944531,0.0006128813,0.0005614761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004177783,"about_ca_system_score_gemma":0.000596669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002399852,"about_ca_topic_score_gemma":0.002719098,"domain_scores_codex":[0.9996687,0.00007343015,0.00002397681,0.0000274787,0.00007125005,0.0001351391],"domain_scores_gemma":[0.9999136,0.00002099978,0.0000135419,0.00001558697,0.00001302742,0.00002324801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005864541,0.0001544526,0.0005054188,0.00006346126,0.00001128359,0.0001380059,0.00003270536,0.00009511257,0.9959714,0.0002323392,0.0001502657,0.002059174],"study_design_scores_gemma":[0.00007415493,0.0006192903,0.008167341,0.000007668655,0.00002328347,0.0001805914,0.0001283835,0.0006130637,0.9876456,0.00005677106,0.002477866,0.000006007131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939733,0.00182738,0.0005921255,0.0002121018,0.00007246545,0.00003808768,0.0004422854,0.00005387404,0.002788325],"genre_scores_gemma":[0.9928503,0.001129132,0.0005092051,0.00009616648,0.00002697718,0.00005004529,0.0006193554,0.00000918876,0.004709681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003099474,"threshold_uncertainty_score":0.01036876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06951794238265266,"score_gpt":0.3587007630069842,"score_spread":0.2891828206243315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}