{"id":"W1994524871","doi":"10.1097/tp.0b013e3182007be2","title":"Anti-BK Virus Mechanisms of Sirolimus and Leflunomide Alone and in Combination: Toward a New Therapy for BK Virus Infection","year":2010,"lang":"en","type":"article","venue":"Transplantation","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Calgary; Alberta Health; Alberta Health Services","funders":"Canadian Institutes of Health Research","keywords":"Leflunomide; BK virus; Sirolimus; Protein kinase B; PI3K/AKT/mTOR pathway; Immunosuppression; Phosphorylation; Cancer research; Medicine; Biology; Signal transduction; Immunology; Nephropathy; Internal medicine; Endocrinology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004906087,0.0005431823,0.0008681758,0.0006835747,0.0001924634,0.0007084294,0.0006760515,0.0005161662,0.00143544],"category_scores_gemma":[0.0001479083,0.0001977874,0.000508668,0.0002557444,0.0003600372,0.0007210908,0.0003278983,0.001280601,0.000304323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002971601,"about_ca_system_score_gemma":0.0002873813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001978353,"about_ca_topic_score_gemma":0.0007551648,"domain_scores_codex":[0.9998015,0.00005129807,0.00001982305,0.0000300936,0.00005561066,0.00004168587],"domain_scores_gemma":[0.9999073,0.00002104636,0.00002552625,0.000006048122,0.00001237639,0.00002771248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008618622,0.004585244,0.003429466,0.002476696,0.0006069504,0.0008940224,0.0001921258,0.002141117,0.6024207,0.00271209,0.003070535,0.3688524],"study_design_scores_gemma":[0.009092363,0.06128475,0.03223287,0.0006078383,0.00227593,0.008431747,0.0002625808,0.01355113,0.6912543,0.002879689,0.1779616,0.0001652176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6535941,0.3134631,0.01708282,0.003264723,0.0008218058,0.0006545269,0.0004055079,0.0004733274,0.01024007],"genre_scores_gemma":[0.8757119,0.1012699,0.0137653,0.001588304,0.0009662401,0.0004137416,0.0005491935,0.00004467701,0.005690808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143544,"threshold_uncertainty_score":0.004801989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674071301288772,"score_gpt":0.2775098465638506,"score_spread":0.2607691335509629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}