{"id":"W1994547945","doi":"10.1016/j.freeradbiomed.2010.11.010","title":"Human prostaglandin H synthase (hPHS)-1- and hPHS-2-dependent bioactivation, oxidative macromolecular damage, and cytotoxicity of dopamine, its precursor, and its metabolites","year":2010,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Homovanillic acid; Chemistry; Biochemistry; Catalase; Arachidonic acid; Dopamine; Oxidative stress; Reactive oxygen species; Superoxide dismutase; Enzyme; Biology; In vitro; Endocrinology; Serotonin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002226527,0.0002280261,0.0001543286,0.0002212524,0.0001747032,0.0001587648,0.000147463,0.0001957074,0.001279353],"category_scores_gemma":[0.0002518218,0.0001433659,0.0002084271,0.00020715,0.0002389617,0.0002490159,0.0001137599,0.0003008354,0.0002037601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395278,"about_ca_system_score_gemma":0.0002487845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000885428,"about_ca_topic_score_gemma":0.001284065,"domain_scores_codex":[0.9998469,0.00004702142,0.00001271347,0.00002642336,0.00002764321,0.00003920467],"domain_scores_gemma":[0.9998553,0.00005093326,0.00002461922,0.00002680853,0.00001525674,0.00002700681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002754835,0.0001255162,0.001263929,0.0000584388,0.00002930777,0.0001348932,0.00006211607,0.0001648252,0.9913502,0.0002289198,0.00005639112,0.003770661],"study_design_scores_gemma":[0.0000304795,0.0007869514,0.005569188,0.000002592745,0.00001939802,0.0002620864,0.00002604083,0.0004335171,0.9920927,0.00007412976,0.0006988109,0.000004037822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996414,0.00189652,0.001063452,0.00002834654,0.00001396588,0.00001585355,0.0001327733,0.000007386631,0.0004275678],"genre_scores_gemma":[0.9963283,0.000817979,0.0007907657,0.00001764231,0.0000122585,0.00001851942,0.0005948476,0.000003831431,0.001415905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279353,"threshold_uncertainty_score":0.004279852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109672923517761,"score_gpt":0.2884205562126395,"score_spread":0.2774532638608633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}