{"id":"W1994547945","doi":"10.1016/j.freeradbiomed.2010.11.010","title":"Human prostaglandin H synthase (hPHS)-1- and hPHS-2-dependent bioactivation, oxidative macromolecular damage, and cytotoxicity of dopamine, its precursor, and its metabolites","year":2010,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Homovanillic acid; Chemistry; Biochemistry; Catalase; Arachidonic acid; Dopamine; Oxidative stress; Reactive oxygen species; Superoxide dismutase; Enzyme; Biology; In vitro; Endocrinology; Serotonin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008079578,0.0002844895,0.0007413275,0.0002098697,0.0001644509,0.000007162867,0.0000798702,0.0003545126,0.00009768421],"category_scores_gemma":[0.001878092,0.0001931507,0.00002704658,0.0001288931,0.001379958,0.00008878856,0.0001207547,0.0005137501,9.532894e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008667394,"about_ca_system_score_gemma":0.00004631383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005001193,"about_ca_topic_score_gemma":0.00003907777,"domain_scores_codex":[0.9984666,0.0001660932,0.0004025919,0.0004779471,0.000180615,0.0003062208],"domain_scores_gemma":[0.9986559,0.0003362856,0.0001811263,0.000240279,0.0001234222,0.0004629455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002781182,0.0001094599,0.04741152,0.0004183658,0.0001348674,0.00005846942,0.0003819402,1.125252e-8,0.9435849,0.005858718,0.0001934419,0.001570247],"study_design_scores_gemma":[0.01138476,0.003118086,0.2475798,0.0004636397,0.0005231814,0.0005276508,0.0001471285,0.000227373,0.7313659,0.001386115,0.002880887,0.0003955242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917794,0.005407874,0.00007024619,0.001502283,0.0001428448,0.0008173286,0.00007426176,0.00003382788,0.0001719456],"genre_scores_gemma":[0.9981555,0.0007385429,0.0001763989,0.0003288526,0.000306749,0.00003640026,0.0000729964,0.000018552,0.0001660352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2122189,"threshold_uncertainty_score":0.7876458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109672923517761,"score_gpt":0.2884205562126395,"score_spread":0.2774532638608633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}