{"id":"W1994563738","doi":"10.1021/jm301588r","title":"Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancer Research UK; Wellcome Trust","keywords":"Bromodomain; Chemistry; BRD4; Epigenetics; Acetylation; Cytotoxicity; Myeloid leukemia; Ligand (biochemistry); Gene knockdown; Cancer research; Biochemistry; Combinatorial chemistry; Stereochemistry; In vitro; Apoptosis; Receptor; Gene; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002713033,0.000518341,0.0004347202,0.0003039032,0.0001459081,0.0002866288,0.0005524921,0.0002463543,0.001122499],"category_scores_gemma":[0.0001877233,0.0001934676,0.000257879,0.0003204553,0.0001814773,0.0002174445,0.0002072411,0.0004911363,0.0003925154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003968585,"about_ca_system_score_gemma":0.0002873029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005628507,"about_ca_topic_score_gemma":0.002033663,"domain_scores_codex":[0.9998575,0.00003142574,0.00001203528,0.00002181569,0.00004318453,0.00003401863],"domain_scores_gemma":[0.9999241,0.0000133126,0.00002100965,0.000008588172,0.00001900502,0.00001403924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003774544,0.0002748146,0.0002946528,0.0002391577,0.0000336538,0.0001863213,0.00005115291,0.003672855,0.9832057,0.0005556253,0.0003523299,0.01075639],"study_design_scores_gemma":[0.0003100263,0.002159256,0.001363178,0.00001788913,0.00005551593,0.00030619,0.00003412945,0.00245895,0.9830808,0.0001526657,0.01004056,0.00002084398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740729,0.008838814,0.009994372,0.000253896,0.00006064269,0.0003421112,0.001001581,0.0001643959,0.005271324],"genre_scores_gemma":[0.9800132,0.006160562,0.00910862,0.00009030817,0.00001499125,0.0001243708,0.0009835161,0.00002991409,0.003474503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001122499,"threshold_uncertainty_score":0.003755152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00478282702163727,"score_gpt":0.2285439622458426,"score_spread":0.2237611352242053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}