{"id":"W1994600783","doi":"10.1182/blood-2009-03-209221","title":"ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"RANKL; Osteoprotegerin; Bone remodeling; Osteoblast; Internal medicine; Bone marrow; Endocrinology; Transplantation; Haematopoiesis; Cancer research; Stem cell; Biology; Medicine; Activator (genetics); Receptor; Cell biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887838,0.001015245,0.0004373534,0.001143644,0.0003851977,0.0004089335,0.000248438,0.0006294661,0.002881154],"category_scores_gemma":[0.0001913572,0.0002814861,0.0003504543,0.000364485,0.0007144323,0.0002123335,0.0003725473,0.00077044,0.0007821371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002818704,"about_ca_system_score_gemma":0.0002245277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003210161,"about_ca_topic_score_gemma":0.0004549096,"domain_scores_codex":[0.9997304,0.00003879712,0.00003824776,0.00006400031,0.00008289739,0.00004552354],"domain_scores_gemma":[0.999587,0.0000364534,0.0001789371,0.0000380674,0.00001755865,0.0001419514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005550472,0.000132507,0.001052321,0.0000720964,0.00001667929,0.00149467,0.00001972672,0.00005938294,0.99511,0.0001891865,0.0001051822,0.00119319],"study_design_scores_gemma":[0.00023894,0.002462753,0.0539747,0.00004416018,0.0001254889,0.03833879,0.0001374532,0.00183661,0.8928689,0.0003718375,0.00956821,0.0000322189],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935325,0.00121526,0.001688457,0.0001193169,0.0000445956,0.00004652557,0.001034104,0.0001548923,0.002164177],"genre_scores_gemma":[0.9907519,0.0008088882,0.001704009,0.0001119602,0.00005057244,0.00006484416,0.002195152,0.00005607616,0.004256554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002881154,"threshold_uncertainty_score":0.009638369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005912172176781414,"score_gpt":0.2099385419318154,"score_spread":0.204026369755034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}