{"id":"W1994637727","doi":"10.1158/0008-5472.sabcs-09-2085","title":"Interim Results of BACH: Randomized Phase II Trial Evaluating the Safety of Two Chemotherapy Regimens as Adjuvant Therapy in Patients with HER2-Positive Breast Cancer: PLD + Cyclophosphamide + Trastuzumab (PLD+C+H), or Doxorubicin + Cyclophosphomide (A+C), Each Followed by Paclitaxel + Trastuzumab (T+H).","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Medicine; Interim analysis; Breast cancer; Ejection fraction; Internal medicine; Regimen; Cardiotoxicity; Trastuzumab; Cyclophosphamide; Asymptomatic; Chemotherapy; Surgery; Cancer; Gastroenterology; Randomized controlled trial; Urology; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002746443,0.001025348,0.001258936,0.0002514887,0.0002677854,0.0008465613,0.0006172277,0.0009253985,0.01146309],"category_scores_gemma":[0.002940122,0.0002678385,0.001043132,0.0001599569,0.001004422,0.001087136,0.0006021771,0.001829709,0.001356043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004924747,"about_ca_system_score_gemma":0.001023293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003614122,"about_ca_topic_score_gemma":0.0008653249,"domain_scores_codex":[0.9992369,0.0004988447,0.00002947581,0.00009027609,0.00004602153,0.00009851401],"domain_scores_gemma":[0.9986004,0.0003350294,0.0003574631,0.0001376312,0.00006440798,0.0005050417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9617726,0.004162624,0.001985875,0.0003984387,0.0005713903,0.00003613084,0.00005602761,0.0009749106,0.003643121,0.0004512343,0.004150021,0.02179769],"study_design_scores_gemma":[0.9296606,0.06196659,0.004090964,0.00003996357,0.0004858708,0.00003986696,0.000021072,0.0005889999,0.0008714461,0.0004962682,0.001723888,0.00001462301],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749056,0.004803332,0.001214888,0.001816233,0.000684796,0.003990875,0.004403972,0.0002195775,0.007960839],"genre_scores_gemma":[0.9768165,0.001380765,0.002480635,0.001752362,0.000530167,0.004651085,0.00487293,0.0000422933,0.007473204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01146309,"threshold_uncertainty_score":0.03834778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02825623865745958,"score_gpt":0.3933462065226312,"score_spread":0.3650899678651716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}