{"id":"W1994657894","doi":"10.1111/j.1474-9726.2007.00301.x","title":"Werner syndrome protein prevents DNA breaks upon chromatin structure alteration","year":2007,"lang":"en","type":"article","venue":"Aging Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"University of Texas Southwestern Medical Center; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute on Aging; Université Laval; Wayne State University","keywords":"Werner syndrome; Biology; Helicase; Chromatin; Bloom syndrome; Genome instability; Nucleoplasm; Premature aging; RecQ helicase; Genetics; Cell biology; DNA repair; CTCF; DNA; Molecular biology; DNA damage; Nucleolus; Gene; Transcription factor; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009700221,0.0003910116,0.0001869821,0.0001758988,0.00008375249,0.0001608813,0.000154706,0.0002308472,0.001185191],"category_scores_gemma":[0.0001641058,0.0000896048,0.0001286932,0.00007782025,0.0002330076,0.0001343668,0.0002065174,0.0002341729,0.0004261656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001235356,"about_ca_system_score_gemma":0.0001187643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002074064,"about_ca_topic_score_gemma":0.0003548145,"domain_scores_codex":[0.9999086,0.00002119273,0.000009104595,0.00002239697,0.00002248105,0.00001625579],"domain_scores_gemma":[0.9999163,0.00001652549,0.00002807793,0.00001188082,0.000006837312,0.00002039427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002949229,0.000005415694,0.000112249,0.0000213523,0.000003173443,0.0001013561,0.000004352662,0.0000108279,0.9989417,0.00006907934,0.00002169141,0.0006792038],"study_design_scores_gemma":[0.000009518532,0.0001518178,0.003112704,0.000005710594,0.00001115582,0.001073783,0.00001139846,0.0001411969,0.9912942,0.00006757724,0.004118268,0.000002632233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879411,0.003442017,0.005624036,0.0001176507,0.000051981,0.00003318048,0.0003567653,0.0002987585,0.002134489],"genre_scores_gemma":[0.9940362,0.001073307,0.001743345,0.00003748454,0.000009630269,0.00001812693,0.0006314182,0.00002958633,0.002420933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001185191,"threshold_uncertainty_score":0.003964841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00356062995558279,"score_gpt":0.2165628840264363,"score_spread":0.2130022540708535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}