{"id":"W1994657894","doi":"10.1111/j.1474-9726.2007.00301.x","title":"Werner syndrome protein prevents DNA breaks upon chromatin structure alteration","year":2007,"lang":"en","type":"article","venue":"Aging Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"University of Texas Southwestern Medical Center; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute on Aging; Université Laval; Wayne State University","keywords":"Werner syndrome; Biology; Helicase; Chromatin; Bloom syndrome; Genome instability; Nucleoplasm; Premature aging; RecQ helicase; Genetics; Cell biology; DNA repair; CTCF; DNA; Molecular biology; DNA damage; Nucleolus; Gene; Transcription factor; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001961423,0.0001432828,0.00009508161,0.00003564468,0.00005891313,0.00002700611,0.0001432217,0.0001354801,0.00005529797],"category_scores_gemma":[0.0000119695,0.0001401473,0.00005174305,0.00005525331,0.00001274946,0.000005655926,0.00007481565,0.00008321775,0.00002216211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002071971,"about_ca_system_score_gemma":0.00002579883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001938816,"about_ca_topic_score_gemma":0.00002408052,"domain_scores_codex":[0.9990769,0.00003715547,0.0001751038,0.0003105721,0.0001438539,0.0002563884],"domain_scores_gemma":[0.9995059,0.000003566425,0.00008515072,0.0003117203,0.00002737481,0.00006625856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001042838,0.00002797417,0.000134409,0.0000342123,0.00001196116,0.00001887528,0.00004073649,0.00001870203,0.998489,0.00002559707,0.0001389168,0.001049159],"study_design_scores_gemma":[0.0003062677,0.0001355264,0.001022934,0.0000284854,0.000009413889,0.00005574675,0.00001203108,0.00009331486,0.9950011,0.0002315883,0.002934567,0.0001690174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932177,0.00009723427,0.005307952,0.00002809236,0.0001551363,0.0003232501,0.000007942795,0.00003461019,0.0008280533],"genre_scores_gemma":[0.9932047,0.000001694336,0.003591236,0.0001113973,0.000134951,0.000008221278,0.0001380734,0.00002999803,0.002779713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00348792,"threshold_uncertainty_score":0.5715042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00356062995558279,"score_gpt":0.2165628840264363,"score_spread":0.2130022540708535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}