{"id":"W1994687618","doi":"10.1074/jbc.m003775200","title":"The Trio Guanine Nucleotide Exchange Factor Is a RhoA Target","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"RHOA; Pleckstrin homology domain; Guanine nucleotide exchange factor; Biology; Cell biology; Molecular biology; GTPase; Chemistry; Phosphorylation; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007987323,0.0004136026,0.000193339,0.0003178644,0.0003317059,0.0003823889,0.0001870701,0.0003244046,0.00111531],"category_scores_gemma":[0.00006979113,0.000112509,0.0002720607,0.0002175216,0.0002560072,0.0001825975,0.0002952444,0.0004583699,0.0007592078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004916443,"about_ca_system_score_gemma":0.000310814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005332101,"about_ca_topic_score_gemma":0.0006354895,"domain_scores_codex":[0.9999005,0.00001255714,0.000004942664,0.00003092092,0.00003078827,0.00002045993],"domain_scores_gemma":[0.9999565,0.000003121151,0.00001377778,0.000004241612,0.000005600365,0.00001666328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004133262,0.00001258414,0.0002003585,0.00003206267,0.000005022596,0.0001229299,0.000007827103,0.00005201526,0.9963297,0.0006911082,0.0001402425,0.002364811],"study_design_scores_gemma":[0.00002115984,0.0001294302,0.01124542,0.00001404119,0.00002074865,0.001771567,0.00003970161,0.001659933,0.9573881,0.0004968462,0.02719651,0.0000164809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9407943,0.01187343,0.0291473,0.0008707054,0.0001666976,0.0001095127,0.001116109,0.0009291781,0.01499271],"genre_scores_gemma":[0.9757759,0.004052209,0.007245325,0.0001397577,0.00003295658,0.00005691964,0.001581434,0.00006062139,0.01105491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00111531,"threshold_uncertainty_score":0.003731132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808868831556315,"score_gpt":0.2495749331158233,"score_spread":0.2314862448002602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}