{"id":"W1994702653","doi":"10.1016/j.ymthe.2004.08.016","title":"Retroviral transduction of hematopoietic cells differentiated from human embryonic stem cell-derived CD45negPFV hemogenic precursors","year":2004,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"","keywords":"Biology; Haematopoiesis; Embryonic stem cell; Transduction (biophysics); Transgene; Cell biology; Progenitor cell; Hemangioblast; Stem cell; CD34; Molecular biology; Retrovirus; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006252211,0.0002700747,0.0002600118,0.00005745046,0.00005895308,0.00001876267,0.0002430187,0.0002019195,0.00004347633],"category_scores_gemma":[0.000001434425,0.0002754325,0.0002549486,0.0001155669,0.00006370151,0.000003845909,0.00003107181,0.0001191446,0.000006977619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002243995,"about_ca_system_score_gemma":0.00003747323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004974268,"about_ca_topic_score_gemma":0.000009444327,"domain_scores_codex":[0.9987336,0.00005900726,0.0002986778,0.0004322508,0.0001918481,0.0002845867],"domain_scores_gemma":[0.9992495,0.000003673945,0.0001026619,0.000508482,0.00005125059,0.00008450038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007438219,0.0001419645,0.00006098798,0.00002579671,0.0001241666,0.000005029185,0.0002931867,0.002691416,0.9959003,0.00001510011,0.00001451559,0.0006531476],"study_design_scores_gemma":[0.002151907,0.0004576941,0.0007468049,0.00002355864,0.00003811053,0.000004006703,0.00009360098,0.0000182604,0.9957981,0.0001509056,0.0002299308,0.0002871977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589714,0.004233107,0.03616892,0.00003866791,0.0001817343,0.0002875751,0.00002330679,0.00003281432,0.00006248076],"genre_scores_gemma":[0.998576,0.0004111899,0.0005252403,0.00005150292,0.0000649767,0.00002081231,0.0001635697,0.00006333314,0.0001233816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0396046,"threshold_uncertainty_score":0.9999698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006754603645677253,"score_gpt":0.2447535704958178,"score_spread":0.2379989668501406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}