{"id":"W1994725538","doi":"10.1128/jvi.02309-07","title":"Control of mRNA Export by Adenovirus E4orf6 and E1B55K Proteins during Productive Infection Requires E4orf6 Ubiquitin Ligase Activity","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Biology; Ubiquitin; F-box protein; Cell biology; Nuclear export signal; Molecular biology; Cullin; Biochemistry; Cell nucleus; Gene; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003563676,0.0003620162,0.0002723038,0.0001738907,0.0002242555,0.000553583,0.0002737569,0.0003232229,0.0009019824],"category_scores_gemma":[0.0002674499,0.000200044,0.000508662,0.0001218092,0.0003974923,0.0002928226,0.0002976118,0.0004650701,0.0004804392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006241305,"about_ca_system_score_gemma":0.0002089275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001063572,"about_ca_topic_score_gemma":0.001046404,"domain_scores_codex":[0.9997167,0.0000435393,0.00005142184,0.00005895218,0.00006493205,0.00006449559],"domain_scores_gemma":[0.9997692,0.00004935254,0.00007075685,0.0000434903,0.00002324225,0.00004399607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000987212,0.0000160951,0.0003642169,0.00001306622,0.000002976029,0.0000290286,0.00001461971,0.00006810675,0.9987358,0.0001693466,0.00001074242,0.0004773397],"study_design_scores_gemma":[0.00001385983,0.0001220214,0.004020631,0.000003213044,0.000005578423,0.0001633331,0.00002934492,0.001220832,0.9932536,0.00006178582,0.001098017,0.000007761975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996711,0.0003778435,0.002134547,0.00002745662,0.00001912285,0.00001183265,0.0001421738,0.00002891104,0.0005470329],"genre_scores_gemma":[0.9948646,0.0001631443,0.00315499,0.00001463716,0.000004537338,0.00001501451,0.0003684657,0.00001943194,0.001395281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063572,"threshold_uncertainty_score":0.004528463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418154157246169,"score_gpt":0.2787896263108628,"score_spread":0.2646080847384011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}