{"id":"W1994725538","doi":"10.1128/jvi.02309-07","title":"Control of mRNA Export by Adenovirus E4orf6 and E1B55K Proteins during Productive Infection Requires E4orf6 Ubiquitin Ligase Activity","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Biology; Ubiquitin; F-box protein; Cell biology; Nuclear export signal; Molecular biology; Cullin; Biochemistry; Cell nucleus; Gene; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005637818,0.0001746333,0.0003785751,0.0001535861,0.0001176121,0.000007368113,0.0001497377,0.0002118266,0.00002248893],"category_scores_gemma":[0.0002450567,0.0001576362,0.0001192387,0.00009800724,0.0003655737,0.00002387074,0.00007215603,0.0003327812,0.000001485576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003574475,"about_ca_system_score_gemma":0.0003154345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003687411,"about_ca_topic_score_gemma":0.00005218135,"domain_scores_codex":[0.9984598,0.0002991929,0.0004267001,0.0002735915,0.0002424838,0.0002981963],"domain_scores_gemma":[0.9987838,0.00002253191,0.0005532323,0.0002476783,0.0002649343,0.0001277893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008900759,0.000308217,0.01825991,0.00003444607,0.0002137038,0.00003785881,0.00007815751,0.00005033564,0.9709355,0.000003237784,0.0002515781,0.0009263055],"study_design_scores_gemma":[0.002351684,0.008836932,0.0397759,0.00001785978,0.00003066305,0.0008493646,0.00001221751,0.0000101678,0.9474127,0.0000448361,0.0005290724,0.0001285456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965928,0.001876551,0.0003534326,0.0006860937,0.0001219459,0.0003172759,0.00001862388,0.00000522072,0.00002805205],"genre_scores_gemma":[0.9981142,0.00110365,0.0001007083,0.0000970698,0.0004473366,0.00001828369,0.000003291907,0.00002505115,0.00009045674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02352274,"threshold_uncertainty_score":0.6428217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418154157246169,"score_gpt":0.2787896263108628,"score_spread":0.2646080847384011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}