{"id":"W1994726114","doi":"10.1158/1538-7445.am2011-2136","title":"Abstract 2136: Expression of fusion proteins in acute myeloid leukemia cells increases sensitivity to histone deacetylase inhibitors","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Vorinostat; Programmed cell death; Biology; Histone deacetylase; DNA damage; Cancer research; Histone deacetylase inhibitor; Molecular biology; Histone; Apoptosis; Cell biology; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001271868,0.0003285852,0.000398643,0.0001816045,0.0001431655,0.0003192888,0.0002056236,0.0003807432,0.002862256],"category_scores_gemma":[0.0001091571,0.0001314505,0.0002825831,0.0003494379,0.0001806847,0.0001286378,0.0001611123,0.0006408319,0.001086198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002658343,"about_ca_system_score_gemma":0.0001515591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004452197,"about_ca_topic_score_gemma":0.0003662322,"domain_scores_codex":[0.9997877,0.00003220422,0.00002773611,0.00003457695,0.0000703268,0.00004742701],"domain_scores_gemma":[0.999908,0.00001680915,0.0000234421,0.00001340903,0.00001397146,0.00002440256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000970659,0.00004013557,0.00009341612,0.00002392268,0.000003664728,0.00003672402,0.000007414279,0.00002562002,0.9991522,0.00002847382,0.00007022917,0.0004211751],"study_design_scores_gemma":[0.00002380431,0.0005558684,0.003377126,0.000006545074,0.00001235288,0.0003366997,0.00001933862,0.0003879238,0.992364,0.0000200487,0.002893194,0.000003164623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932141,0.001676782,0.001595118,0.0002025447,0.00007133251,0.00005274824,0.001265694,0.0001215903,0.001800163],"genre_scores_gemma":[0.9884185,0.0009402743,0.002205307,0.00009322384,0.00002570287,0.00006700173,0.003271663,0.00002854754,0.0049499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002862256,"threshold_uncertainty_score":0.009575188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05718878108002325,"score_gpt":0.369191659511069,"score_spread":0.3120028784310458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}