{"id":"W1994736754","doi":"10.2353/ajpath.2008.080378","title":"Transgenic Induction of Vascular Endothelial Growth Factor-C Is Strongly Angiogenic in Mouse Embryos but Leads to Persistent Lymphatic Hyperplasia in Adult Tissues","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Sydäntutkimussäätiö; Novo Nordisk Fonden; Biomedicum Helsinki-säätiö; European Commission; Sigrid Juséliuksen Säätiö; Ida Montinin Säätiö; Novo Nordisk; Foundation for Cardiovascular Research","keywords":"Lymphatic system; Hyperplasia; Embryo; Pathology; Transgene; Biology; Genetically modified mouse; Vascular endothelial growth factor C; Vascular endothelial growth factor; Angiogenesis; Vascular endothelial growth factor A; Immunology; Medicine; Cancer research; VEGF receptors; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639625,0.0001814563,0.0008694595,0.0006353728,0.00002301237,0.000003181884,0.00014156,0.00006925797,0.00005661969],"category_scores_gemma":[0.0002261766,0.0001527899,0.0004042474,0.0003897609,0.0002300926,0.00009193771,0.00001385692,0.00005577321,0.00001059573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049395,"about_ca_system_score_gemma":0.0003321721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003065874,"about_ca_topic_score_gemma":0.00002296901,"domain_scores_codex":[0.9980798,0.0002595191,0.0007927113,0.0002104152,0.0003690259,0.0002885097],"domain_scores_gemma":[0.9989231,0.00008015319,0.0003595134,0.0001973037,0.0002243744,0.0002155696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009328037,0.0006953582,0.8216173,0.0001036589,0.0002072111,0.001306111,0.01185345,0.00009563017,0.1599293,0.00001143009,0.00003727321,0.003210437],"study_design_scores_gemma":[0.01261663,0.009822563,0.8872143,0.0004726171,0.0005383239,0.01491698,0.01946337,0.00005309519,0.05442928,0.00001311852,0.00002571515,0.0004340031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985574,0.0006902706,0.0001144472,0.0001982489,0.0001220734,0.000240299,0.00002903418,0.000007484622,0.00004071896],"genre_scores_gemma":[0.9987037,0.0002737675,0.0005739809,0.0002304213,0.0001223202,0.000009196092,0.00000255674,0.00002324171,0.00006086258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1055001,"threshold_uncertainty_score":0.6230593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721610653731097,"score_gpt":0.2580150299013554,"score_spread":0.2407989233640445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}