{"id":"W1994736754","doi":"10.2353/ajpath.2008.080378","title":"Transgenic Induction of Vascular Endothelial Growth Factor-C Is Strongly Angiogenic in Mouse Embryos but Leads to Persistent Lymphatic Hyperplasia in Adult Tissues","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Sydäntutkimussäätiö; Novo Nordisk Fonden; Biomedicum Helsinki-säätiö; European Commission; Sigrid Juséliuksen Säätiö; Ida Montinin Säätiö; Novo Nordisk; Foundation for Cardiovascular Research","keywords":"Lymphatic system; Hyperplasia; Embryo; Pathology; Transgene; Biology; Genetically modified mouse; Vascular endothelial growth factor C; Vascular endothelial growth factor; Angiogenesis; Vascular endothelial growth factor A; Immunology; Medicine; Cancer research; VEGF receptors; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004508649,0.0007423084,0.0004834936,0.001309525,0.0004163764,0.0007470232,0.0006311742,0.001050451,0.003220301],"category_scores_gemma":[0.0004104551,0.0007065443,0.000553031,0.0004217541,0.0008436027,0.0004773057,0.0004179201,0.002319712,0.001089769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007533851,"about_ca_system_score_gemma":0.0005696553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001608151,"about_ca_topic_score_gemma":0.002007877,"domain_scores_codex":[0.9993469,0.00006422431,0.00006960601,0.0001515941,0.0002017691,0.0001659321],"domain_scores_gemma":[0.99854,0.0003348393,0.0004386082,0.0001792561,0.00009204579,0.0004152397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001020048,0.00001882083,0.00009892303,0.00001138061,0.000004134229,0.0001227585,0.00001094587,0.00004190087,0.9990793,0.0001962258,0.00004272578,0.0002708634],"study_design_scores_gemma":[0.00003430802,0.00008328486,0.002024636,0.000006353644,0.00001800751,0.0004114037,0.00002586549,0.0007865379,0.9951767,0.00007333508,0.001352878,0.000006735174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823857,0.001603887,0.009724593,0.0003757123,0.0001470023,0.00008483501,0.001672308,0.00056846,0.003437585],"genre_scores_gemma":[0.9824914,0.0007053633,0.004168871,0.0001301578,0.00004489772,0.00009868221,0.001222583,0.0003461732,0.01079191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003220301,"threshold_uncertainty_score":0.01077294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721610653731097,"score_gpt":0.2580150299013554,"score_spread":0.2407989233640445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}