{"id":"W1994741655","doi":"10.1016/j.bmcl.2014.11.048","title":"Radiosynthesis and ex vivo evaluation of [18F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science","keywords":"Chemistry; Radiosynthesis; Ex vivo; Biodistribution; In vivo; Positron emission tomography; Specific activity; Radiochemistry; Monoamine oxidase B; Monoamine oxidase A; Pet imaging; Stereochemistry; In vitro; Monoamine oxidase; Nuclear medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000722511,0.000746414,0.0003582148,0.0003710637,0.000275075,0.0004503051,0.0007498029,0.0008024964,0.001423935],"category_scores_gemma":[0.0004337679,0.0006509592,0.0003168372,0.0002922188,0.0003616613,0.0005201991,0.000169657,0.0007813385,0.0004296993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003470329,"about_ca_system_score_gemma":0.0004308131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001999693,"about_ca_topic_score_gemma":0.001628336,"domain_scores_codex":[0.9998318,0.00007271994,0.000006464038,0.0000338096,0.00001500765,0.00004016314],"domain_scores_gemma":[0.9998272,0.00007403368,0.00003480332,0.00002513703,0.00001568168,0.00002310627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001774349,0.0001988605,0.0001418706,0.0000969518,0.0000362287,0.0001499407,0.00007836674,0.0005392421,0.9931479,0.0002563851,0.0001493666,0.003430532],"study_design_scores_gemma":[0.0002718432,0.004126026,0.00182312,0.00001491947,0.0002067351,0.001373961,0.00006039339,0.002886134,0.986159,0.00008172191,0.002971768,0.0000242792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966008,0.009593591,0.01863232,0.0002841975,0.00006779119,0.0001694619,0.0005107279,0.0002137666,0.004520141],"genre_scores_gemma":[0.983611,0.00312379,0.008437802,0.00008242622,0.00003754374,0.0001865231,0.0006930298,0.00009876847,0.003729058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001999693,"threshold_uncertainty_score":0.004763484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01846728072944001,"score_gpt":0.2599561789218345,"score_spread":0.2414888981923945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}