{"id":"W1994769512","doi":"10.3109/00498254.2011.614021","title":"A high throughput<i>in vitro</i>mrp2 assay to predict<i>in vivo</i>biliary excretion","year":2011,"lang":"en","type":"article","venue":"Xenobiotica","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Multidrug resistance-associated protein 2; In vivo; Excretion; In vitro; Pharmacology; Chemistry; IC50; Biology; ATP-binding cassette transporter; Biochemistry; Internal medicine; Transporter; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009905051,0.001200187,0.001494656,0.000720301,0.0002790103,0.001050219,0.0005095911,0.001345628,0.001364693],"category_scores_gemma":[0.001318119,0.0004758101,0.0008052023,0.0005776798,0.0003503449,0.0006779229,0.0003953365,0.001100948,0.001965033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005312139,"about_ca_system_score_gemma":0.0005339768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00081148,"about_ca_topic_score_gemma":0.00149775,"domain_scores_codex":[0.9987809,0.0003923335,0.0000836018,0.0002255183,0.0004179257,0.00009973682],"domain_scores_gemma":[0.9989042,0.0003093975,0.0003008256,0.0001513131,0.0002650127,0.00006917748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001946715,0.00009666477,0.00360079,0.0001842196,0.00006852003,0.0001010654,0.00001787467,0.0007959444,0.9837534,0.000110924,0.000428518,0.01064746],"study_design_scores_gemma":[0.00001532483,0.0009006195,0.007795963,0.00002177261,0.0001761219,0.0008037384,0.00003123342,0.006463654,0.9796326,0.0001356318,0.003980608,0.00004274134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5269396,0.01534275,0.4389656,0.0007435397,0.0002418165,0.0006745957,0.006222421,0.004608816,0.006260826],"genre_scores_gemma":[0.840903,0.009625707,0.1354879,0.0005962203,0.0001398371,0.0005936929,0.005279271,0.0003021989,0.007072157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001494656,"threshold_uncertainty_score":0.005238354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403732620785384,"score_gpt":0.2244453106597591,"score_spread":0.2104079844519053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}