{"id":"W1994798199","doi":"10.1016/s1044-5323(02)00043-x","title":"Influence of antibody diversification on the mechanism of haplotype exclusion of immunoglobulin gene expression","year":2002,"lang":"en","type":"review","venue":"Seminars in Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Canada Research Chairs; University of Toronto","funders":"","keywords":"Allelic exclusion; Haplotype; Biology; Allele; Isotype; Antibody; Gene; Genetics; T cell; Immune system; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005248527,0.0004772846,0.00111024,0.0006115653,0.0001794824,0.0008297177,0.0008675171,0.0008339865,0.001110825],"category_scores_gemma":[0.0003491359,0.0001807289,0.0002069303,0.0006458437,0.0006713802,0.0007340854,0.000397634,0.0007679142,0.0008310918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004442719,"about_ca_system_score_gemma":0.0003630492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000308845,"about_ca_topic_score_gemma":0.000369372,"domain_scores_codex":[0.9998767,0.00002660037,0.0000130693,0.00003584479,0.00003107076,0.00001656147],"domain_scores_gemma":[0.9998274,0.00009822051,0.00002663798,0.000009134014,0.00002642854,0.00001216359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003718519,0.00005600317,0.001158493,0.006776378,0.0001109244,0.001278829,0.00009768963,0.0008769265,0.06179461,0.0114986,0.006273058,0.9097066],"study_design_scores_gemma":[0.0001355365,0.0005796811,0.01566602,0.001919906,0.0004601046,0.01236888,0.0002941969,0.000825875,0.05189288,0.01850888,0.8972603,0.00008771039],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003113661,0.9919648,0.001579069,0.0002929214,0.0002550591,0.000006157084,0.00002022335,0.00001723506,0.002750841],"genre_scores_gemma":[0.01713533,0.9798653,0.0008115473,0.0002923306,0.0003577067,0.00001521383,0.00004659682,0.00000352909,0.0014725],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001110825,"threshold_uncertainty_score":0.003716052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04765096022982809,"score_gpt":0.3499917218098019,"score_spread":0.3023407615799738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}