{"id":"W1994827487","doi":"10.1529/biophysj.106.087197","title":"The Cooperative Response of Synaptotagmin I C2A. A Hypothesis for a Ca2+-Driven Molecular Hammer","year":2006,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"National Institute of General Medical Sciences","keywords":"Synaptotagmin 1; Exocytosis; Cooperativity; Synaptotagmin I; Biophysics; Chemistry; Phosphatidylserine; Synaptic vesicle; Membrane; Divalent; Rab; Cell biology; Vesicle; Biochemistry; Biology; GTPase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177344,0.0001130884,0.0001333207,0.00002159985,0.000162965,0.00002883179,0.0001467097,0.00008324801,0.000005255397],"category_scores_gemma":[0.00006885265,0.00007754716,0.0002360641,0.00006011748,0.0001391651,0.000003013075,0.00001560522,0.00008311413,0.000002290187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001180071,"about_ca_system_score_gemma":0.00007657246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007207192,"about_ca_topic_score_gemma":0.00000676194,"domain_scores_codex":[0.9991988,0.0001011708,0.0002282922,0.0001469027,0.0001344695,0.0001903594],"domain_scores_gemma":[0.9994615,0.00005977536,0.0001072676,0.0001540311,0.0001638387,0.00005357351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001499325,0.00008006377,0.0000842388,0.000004138088,0.00006112974,0.000008543192,0.00001861722,0.00008549248,0.9971561,0.0004078574,0.0002749054,0.0003195973],"study_design_scores_gemma":[0.0006360636,0.0005018227,0.002657293,0.00001079993,0.00004349008,0.00002603575,0.00003565397,0.0002527548,0.9776365,0.0001377065,0.01794053,0.0001213206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624726,0.0001461729,0.03669061,0.000385501,0.00006826111,0.0001505052,0.00003098272,0.000003048325,0.00005232322],"genre_scores_gemma":[0.998613,0.00003970819,0.0005917529,0.00004959703,0.0002759296,0.00001456987,0.00007575464,0.00001676448,0.000322922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0361404,"threshold_uncertainty_score":0.3162282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008609484562587106,"score_gpt":0.224469683727836,"score_spread":0.2158601991652489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}