{"id":"W1994870754","doi":"10.1158/0008-5472.can-05-0877","title":"Increased Efficacy and Safety in the Treatment of Experimental Liver Cancer with a Novel Adenovirus-Alphavirus Hybrid Vector","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University","keywords":"Semliki Forest virus; Biology; Viral vector; Genetic enhancement; Transgene; Cancer research; Reporter gene; Replicon; Virology; Vector (molecular biology); Subgenomic mRNA; Suicide gene; Hepatocellular carcinoma; Oncolytic virus; Molecular biology; Gene; Virus; Gene expression; Plasmid; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005940112,0.0003145873,0.0003734083,0.0004333034,0.0001338744,0.0003880522,0.0002074651,0.0003082331,0.001027056],"category_scores_gemma":[0.0003305779,0.000169845,0.0002518095,0.0001972516,0.0002935113,0.0003972029,0.0001877537,0.0006734633,0.0002887892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003048196,"about_ca_system_score_gemma":0.0002653583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002201592,"about_ca_topic_score_gemma":0.0002569376,"domain_scores_codex":[0.999675,0.00007694853,0.00003626705,0.00006512257,0.0001064378,0.00004030963],"domain_scores_gemma":[0.9996713,0.0000971723,0.00005646203,0.00005705806,0.00005575672,0.0000621889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000794323,0.0002653206,0.0005882528,0.00008827667,0.00001823592,0.0000749063,0.00003852012,0.0001587985,0.9830814,0.000719419,0.0001292177,0.01404332],"study_design_scores_gemma":[0.0002094517,0.005875465,0.00382554,0.00001382209,0.00008195789,0.001044563,0.00001749583,0.00170846,0.9791692,0.0001884026,0.007851815,0.00001381955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724352,0.003575315,0.02159185,0.0001622414,0.0001129866,0.0001319805,0.0002161272,0.0002909682,0.001483398],"genre_scores_gemma":[0.9817348,0.001145888,0.01387561,0.00003951637,0.00005266978,0.0001016766,0.0004799205,0.00004208832,0.002527886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027056,"threshold_uncertainty_score":0.003435791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04572691573539742,"score_gpt":0.3739444928814377,"score_spread":0.3282175771460403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}