{"id":"W1994870754","doi":"10.1158/0008-5472.can-05-0877","title":"Increased Efficacy and Safety in the Treatment of Experimental Liver Cancer with a Novel Adenovirus-Alphavirus Hybrid Vector","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University","keywords":"Semliki Forest virus; Biology; Viral vector; Genetic enhancement; Transgene; Cancer research; Reporter gene; Replicon; Virology; Vector (molecular biology); Subgenomic mRNA; Suicide gene; Hepatocellular carcinoma; Oncolytic virus; Molecular biology; Gene; Virus; Gene expression; Plasmid; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004074926,0.0001670999,0.0001827929,0.0001117353,0.0001259207,0.00003085088,0.0002731801,0.00006244574,0.0001118558],"category_scores_gemma":[0.00001133874,0.0001112401,0.00004164686,0.000269676,0.0004329436,0.000005581465,0.00005732156,0.0001464374,0.000002301699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045886,"about_ca_system_score_gemma":0.0004157609,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01215535,"about_ca_topic_score_gemma":0.007539533,"domain_scores_codex":[0.9982094,0.0002438245,0.0001788537,0.0004207264,0.0004896286,0.0004575634],"domain_scores_gemma":[0.9992808,0.00007723384,0.00003884554,0.0004028927,0.0001232494,0.00007704443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01156154,0.0009047109,0.002436237,0.00001581231,0.00006146208,0.00002262024,0.0002655305,0.00007366634,0.9803067,0.0000216026,0.0002467123,0.004083447],"study_design_scores_gemma":[0.004828245,0.005474928,0.01368335,0.00003276648,0.000009084888,0.000008624419,0.0001323969,0.00002612216,0.9658257,0.000002320489,0.009835775,0.0001407057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734732,0.02509978,0.000005460754,0.0001710294,0.00001655354,0.0008210919,0.0001865756,0.000004217564,0.0002221001],"genre_scores_gemma":[0.9947895,0.004012589,0.00002288976,0.00005040042,0.0002349178,0.0006094949,0.0000425647,0.00003104949,0.0002065932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02131631,"threshold_uncertainty_score":0.9944228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04572691573539742,"score_gpt":0.3739444928814377,"score_spread":0.3282175771460403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}