{"id":"W1994899118","doi":"10.1038/ncomms7326","title":"Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; Canada Research Chairs; Ottawa Hospital; University of Ottawa; McGill University; Public Health Ontario; McGill University and Génome Québec Innovation Centre; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Ontario Ministry of Research and Innovation; Medical Research Council; Institut de Cardiométabolisme et Nutrition; Université Pierre et Marie Curie; Ontario Institute for Cancer Research; Agence Nationale de la Recherche; Canadian Institutes of Health Research; National Institute for Health and Care Research; National Institutes of Health; McGill University; Heart and Stroke Foundation of Canada","keywords":"Epigenetics; Biology; CpG site; Genetics; DNA methylation; Single-nucleotide polymorphism; Methylation; Quantitative trait locus; Gene; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006059209,0.0002575105,0.0005366561,0.0006068459,0.0002722317,0.0005476436,0.0003303574,0.0002677155,0.001882068],"category_scores_gemma":[0.001292517,0.0003341196,0.0002684913,0.0008196938,0.0006161736,0.0004419492,0.0009010749,0.0004374462,0.0004400555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000282987,"about_ca_system_score_gemma":0.0001785498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005656578,"about_ca_topic_score_gemma":0.001450227,"domain_scores_codex":[0.9992043,0.0001073206,0.00003605883,0.0003899917,0.0001950456,0.00006733978],"domain_scores_gemma":[0.998614,0.0005491303,0.0004312255,0.0002147775,0.0000801118,0.0001108155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004575546,0.00004746356,0.1532698,0.0001458858,0.0004821919,0.0002992225,0.0001637325,0.0008917616,0.816258,0.0008716163,0.000174824,0.02693817],"study_design_scores_gemma":[0.00002444942,0.0001769849,0.9370298,0.00001680456,0.0001899218,0.000719858,0.0001083307,0.001938336,0.05581556,0.001778975,0.002171632,0.00002935957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900371,0.001405556,0.006640847,0.00009319181,0.00001471185,0.000006044103,0.00068463,0.0001023284,0.001015593],"genre_scores_gemma":[0.9966912,0.0003251551,0.001877633,0.00005430405,0.00001454008,0.00001100881,0.000475147,0.00002107782,0.0005298787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001882068,"threshold_uncertainty_score":0.006296158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022736644726265,"score_gpt":0.2937259634088225,"score_spread":0.2709893186825574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}