{"id":"W1994899118","doi":"10.1038/ncomms7326","title":"Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; Canada Research Chairs; Ottawa Hospital; University of Ottawa; McGill University; Public Health Ontario; McGill University and Génome Québec Innovation Centre; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Ontario Ministry of Research and Innovation; Medical Research Council; Institut de Cardiométabolisme et Nutrition; Université Pierre et Marie Curie; Ontario Institute for Cancer Research; Agence Nationale de la Recherche; Canadian Institutes of Health Research; National Institute for Health and Care Research; National Institutes of Health; McGill University; Heart and Stroke Foundation of Canada","keywords":"Epigenetics; Biology; CpG site; Genetics; DNA methylation; Single-nucleotide polymorphism; Methylation; Quantitative trait locus; Gene; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003360331,0.0001685429,0.0001744337,0.00007663132,0.0001311182,0.0000225189,0.0005667874,0.0005576403,0.00002846054],"category_scores_gemma":[0.0001582197,0.0001777762,0.00007710978,0.0002276201,0.0001223804,0.000007193798,0.0003168423,0.0002300148,0.00001335211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007031714,"about_ca_system_score_gemma":0.0001254282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005566332,"about_ca_topic_score_gemma":0.0003455468,"domain_scores_codex":[0.9986135,0.0002246059,0.00039783,0.0002935817,0.0002962396,0.000174239],"domain_scores_gemma":[0.9974295,0.00003524568,0.0002847518,0.001538747,0.0005919561,0.0001197489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001528679,0.0004026987,0.1080811,0.00003058261,0.0001781645,4.787064e-7,0.0008336348,0.000897468,0.8703481,0.000332019,0.01506359,0.003679319],"study_design_scores_gemma":[0.001977996,0.000417145,0.422227,0.00002485177,0.0001528984,0.000006598551,0.00006982109,0.004037,0.4862486,0.0009524346,0.08336648,0.0005191507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9106373,0.06022793,0.02425089,0.001224765,0.0002242957,0.0006258057,0.0001488033,0.00003507218,0.002625201],"genre_scores_gemma":[0.9923086,0.002006005,0.002981752,0.0001481985,0.00006178251,0.00003367868,0.001768342,0.00003109685,0.0006605074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3840995,"threshold_uncertainty_score":0.7249504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022736644726265,"score_gpt":0.2937259634088225,"score_spread":0.2709893186825574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}