{"id":"W1994925836","doi":"10.1089/gtmb.2011.0327","title":"The AmpliChip <sup>®</sup> CYP450 Test and Response to Treatment in Schizophrenia and Obsessive Compulsive Disorder: A Pilot Study and Focus on Cases with Abnormal CYP2D6 Drug Metabolism","year":2012,"lang":"en","type":"article","venue":"Genetic Testing and Molecular Biomarkers","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"CYP2D6; CYP2C19; Genotyping; Pharmacogenetics; Medicine; Schizophrenia (object-oriented programming); Analysis of variance; Drug; Internal medicine; Prospective cohort study; Psychiatry; Pharmacology; Genotype; Biology; Genetics; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006781879,0.0003927917,0.0002803414,0.000654043,0.0002395646,0.0001903799,0.0002642426,0.0004129682,0.001390115],"category_scores_gemma":[0.00167817,0.0001648371,0.0003157733,0.0003869892,0.0003320106,0.0001636275,0.0003279246,0.0003252178,0.000237254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002533662,"about_ca_system_score_gemma":0.0001716877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001496991,"about_ca_topic_score_gemma":0.001382941,"domain_scores_codex":[0.9994155,0.0002835286,0.00005479546,0.00009607471,0.00008325729,0.00006681679],"domain_scores_gemma":[0.9984145,0.0007501695,0.0003811,0.0001036946,0.00009938127,0.00025114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.001459624,0.0003808037,0.9834806,0.00002047892,0.00004876657,0.001939002,0.0001533685,0.00008643138,0.005011067,0.00001584793,0.00007011566,0.007333864],"study_design_scores_gemma":[0.00008658279,0.002883077,0.9855804,0.000003589575,0.00004996759,0.008829251,0.0001407264,0.0005348821,0.001713651,0.00002810827,0.0001422553,0.000007391844],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996561,0.00006896965,0.00009850196,0.00001363155,9.298953e-7,0.00001231461,0.00003408457,0.000002681759,0.0001126898],"genre_scores_gemma":[0.9995738,0.00002882934,0.0002287218,0.0000149116,0.000004280557,0.00001209751,0.00007091892,0.000002003784,0.00006449628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001496991,"threshold_uncertainty_score":0.004650474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04705397687062119,"score_gpt":0.3447609642002677,"score_spread":0.2977069873296466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}