{"id":"W1994931667","doi":"10.5539/enrr.v3n3p98","title":"Acetylcholine Deficiency in Caenorhabditis elegans Induced by Hyperthermia Can Be Compensated by ACh-esterase Inhibition or Activation of GAR-3 mAChRs","year":2013,"lang":"en","type":"article","venue":"Environment and Natural Resources Research","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Caenorhabditis elegans; Neostigmine; Oxotremorine; Pilocarpine; Atropine; Acetylcholine; Muscarinic acetylcholine receptor; Hyperthermia; Biology; Pharmacology; Receptor; Chemistry; Neuroscience; Endocrinology; Biochemistry; Epilepsy; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008729124,0.0004909428,0.0002734559,0.0002684473,0.0001608357,0.0001904075,0.0002804128,0.0004365551,0.001206554],"category_scores_gemma":[0.0001121045,0.0001809513,0.0004375665,0.000116377,0.0002354209,0.0001503777,0.0002481378,0.0006496227,0.0002489903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497825,"about_ca_system_score_gemma":0.0001760983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001298806,"about_ca_topic_score_gemma":0.002225695,"domain_scores_codex":[0.9998659,0.00001184332,0.0000218026,0.00002691464,0.00003302245,0.0000404576],"domain_scores_gemma":[0.9998659,0.0000162361,0.00004970327,0.00001591511,0.000009599327,0.00004256474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008096554,0.00002331016,0.0001148236,0.00002190979,0.00000318063,0.00007264179,0.00000734386,0.00002306198,0.9993698,0.00001984914,0.0000135471,0.0002495706],"study_design_scores_gemma":[0.00004576462,0.0008289697,0.01550593,0.00001913679,0.00003065923,0.0003687537,0.00005127263,0.0009821369,0.9809628,0.00005312861,0.001139613,0.00001199793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977655,0.0003426969,0.0005596793,0.00006495245,0.0000209428,0.00002631389,0.0004591161,0.00006803721,0.000692666],"genre_scores_gemma":[0.9945052,0.0004555614,0.001363467,0.00005846449,0.000005822664,0.00007136694,0.0006605953,0.00002159857,0.002857874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298806,"threshold_uncertainty_score":0.004036307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982938078003721,"score_gpt":0.2654590477734358,"score_spread":0.2456296669933986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}