{"id":"W1994985909","doi":"10.2147/cia.s82128","title":"Modeling clustered activity increase in amyloid-beta positron emission tomographic images with statistical descriptors","year":2015,"lang":"en","type":"article","venue":"Clinical Interventions in Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Positron emission tomography; Positron emission; BETA (programming language); Nuclear medicine; Amyloid (mycology); Positron; Pathology; Nuclear physics; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001137215,0.0001810832,0.0004424146,0.0003756646,0.00005431989,0.0000470328,0.0001175684,0.00009837542,0.00005266899],"category_scores_gemma":[0.0005308451,0.0001428017,0.0002389446,0.0003818985,0.0001831117,0.0002355245,0.0001413095,0.0006225476,0.00001859005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001987538,"about_ca_system_score_gemma":0.0002208817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082161,"about_ca_topic_score_gemma":0.0003460959,"domain_scores_codex":[0.9976683,0.0004627597,0.000669486,0.0004491781,0.0003483477,0.0004019664],"domain_scores_gemma":[0.9985712,0.0002190787,0.00007748698,0.0003275579,0.0001294633,0.0006752227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00227964,0.004597315,0.9830198,0.0001697635,0.0008252899,0.0008915992,0.00007508485,0.000231254,0.00002582008,0.0000494701,0.0002132579,0.007621649],"study_design_scores_gemma":[0.0227129,0.003323747,0.784126,0.008616969,0.001115127,0.00008272488,0.001033935,0.1762254,0.0003501735,0.00181379,0.00001700667,0.0005822802],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889787,0.001245341,0.008301622,0.0004759832,0.00008283023,0.0004560942,0.00002422305,0.00004937609,0.000385813],"genre_scores_gemma":[0.9972042,0.00006069806,0.002426354,0.00004300174,0.00005073935,0.00005258685,0.00007516402,0.00002473255,0.00006253149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1988939,"threshold_uncertainty_score":0.5823284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1661423963463472,"score_gpt":0.4562513480645963,"score_spread":0.2901089517182491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}