{"id":"W1995002220","doi":"10.1371/journal.pone.0043671","title":"ING1 and 5-Azacytidine Act Synergistically to Block Breast Cancer Cell Growth","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Fondation pour la Recherche Médicale; Alberta Cancer Foundation","keywords":"Panobinostat; Epigenetics; Histone deacetylase; Biology; Cancer research; H3K4me3; Histone; Chromatin; Histone deacetylase inhibitor; Cancer epigenetics; Cancer cell; Molecular biology; Cancer; Histone methyltransferase; Biochemistry; DNA; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600993,0.0005279339,0.0004944762,0.0003525068,0.0001592819,0.000277039,0.0003690416,0.0003521998,0.002231218],"category_scores_gemma":[0.00009093506,0.0001676034,0.0002882547,0.0002606669,0.0002206324,0.0001442238,0.0002498013,0.0006781313,0.0005369213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005030895,"about_ca_system_score_gemma":0.0004026297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008990287,"about_ca_topic_score_gemma":0.003287961,"domain_scores_codex":[0.999822,0.00002081606,0.00001576258,0.00003324931,0.00006249747,0.00004578592],"domain_scores_gemma":[0.9999251,0.00001731865,0.00001617573,0.00001034116,0.00000725569,0.00002373219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004551621,0.0002005916,0.0005323836,0.0002083216,0.00003491555,0.00007304706,0.00002941948,0.0003075252,0.9895755,0.0001072839,0.0002975553,0.008178332],"study_design_scores_gemma":[0.00004602376,0.001090487,0.003528261,0.000009431154,0.00006644913,0.0002141967,0.00002482769,0.0005465696,0.9889136,0.0000264325,0.005529855,0.000003888864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770525,0.01130935,0.002200619,0.0004515748,0.0001444427,0.0001347074,0.000627088,0.0003129443,0.007766859],"genre_scores_gemma":[0.9875908,0.003751735,0.002973862,0.0001467167,0.00004013936,0.0000887546,0.0008058001,0.00001945549,0.004582798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002231218,"threshold_uncertainty_score":0.00746417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874024085871423,"score_gpt":0.2343078295625072,"score_spread":0.215567588703793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}