{"id":"W1995002220","doi":"10.1371/journal.pone.0043671","title":"ING1 and 5-Azacytidine Act Synergistically to Block Breast Cancer Cell Growth","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Fondation pour la Recherche Médicale; Alberta Cancer Foundation","keywords":"Panobinostat; Epigenetics; Histone deacetylase; Biology; Cancer research; H3K4me3; Histone; Chromatin; Histone deacetylase inhibitor; Cancer epigenetics; Cancer cell; Molecular biology; Cancer; Histone methyltransferase; Biochemistry; DNA; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043138,0.0001036645,0.0001100664,0.00001767289,0.00004542338,0.0000160326,0.00006739458,0.00008367668,0.00003989682],"category_scores_gemma":[0.00005317252,0.00009940323,0.0000208676,0.00004646689,0.00002176122,0.000003938697,0.00009160625,0.0000449241,0.00001172228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001456961,"about_ca_system_score_gemma":0.00002287887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007657005,"about_ca_topic_score_gemma":0.00002773604,"domain_scores_codex":[0.9993276,0.00002282756,0.0001149448,0.0001843414,0.0001206145,0.0002296787],"domain_scores_gemma":[0.999505,0.00001131554,0.00003349139,0.0001567357,0.00009450851,0.0001989473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003154936,0.0003274423,0.04598526,0.0000376953,0.00004393089,2.623513e-7,0.00003246187,0.000003849649,0.9529211,0.0000440168,0.00008729551,0.0004851449],"study_design_scores_gemma":[0.0002076704,0.0001143435,0.06261119,0.00002357671,0.00006530511,7.989869e-7,0.000007756972,0.0000334143,0.9360749,0.00002289032,0.0006738388,0.0001643397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952945,0.002182908,0.0001570728,0.0003211701,0.00003641316,0.0001226886,0.00003763816,0.000008727238,0.001838865],"genre_scores_gemma":[0.9956298,0.001277947,0.001933955,0.000193459,0.000476773,0.00002219083,0.00002157375,0.00002032692,0.0004239874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01684621,"threshold_uncertainty_score":0.4053546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874024085871423,"score_gpt":0.2343078295625072,"score_spread":0.215567588703793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}