{"id":"W1995026094","doi":"10.3389/fnagi.2014.00183","title":"Genetic variation modifies risk for neurodegeneration based on biomarker status","year":2014,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; Medpace; F. Hoffmann-La Roche; Vanderbilt University; Synarc; Pharmaceutical Research and Manufacturers of America Foundation; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health; Meso Scale Diagnostics","keywords":"Neurodegeneration; Biomarker; Single-nucleotide polymorphism; Genome-wide association study; SNP; Biology; Bonferroni correction; Genetic variation; Disease; Oncology; Genetics; Bioinformatics; Medicine; Internal medicine; Genotype; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002166464,0.0005668682,0.0005099953,0.0009058448,0.0004005744,0.0008533453,0.0004343333,0.0008388002,0.002598479],"category_scores_gemma":[0.0050724,0.0002457855,0.001076838,0.001314235,0.0007287564,0.000333174,0.000560337,0.0007224198,0.0002892066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002233759,"about_ca_system_score_gemma":0.0002944896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00236086,"about_ca_topic_score_gemma":0.002643924,"domain_scores_codex":[0.9980566,0.0006583592,0.0001829059,0.0007748713,0.0001709452,0.0001562883],"domain_scores_gemma":[0.9967817,0.001762798,0.000689782,0.0004536718,0.0001372593,0.0001747878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001496637,0.00008496549,0.9705753,0.00008002538,0.002456368,0.000442006,0.0002754547,0.0009683889,0.01588618,0.0004903442,0.0004197067,0.006824559],"study_design_scores_gemma":[0.0000367305,0.0001457845,0.9940826,0.00002402793,0.0007285536,0.000558288,0.00006611396,0.00171203,0.001026848,0.001117131,0.0004831395,0.00001870965],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955887,0.0005350871,0.002048382,0.0002071242,0.00002379402,0.00001816185,0.0009387408,0.00004902026,0.0005910523],"genre_scores_gemma":[0.9983308,0.00009365157,0.0008561386,0.00007242128,0.00001636645,0.00001530381,0.0004668836,0.00002242993,0.0001259716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002598479,"threshold_uncertainty_score":0.0114575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02987042684949979,"score_gpt":0.2848378428214732,"score_spread":0.2549674159719734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}