{"id":"W1995048593","doi":"10.1021/acs.biochem.5b00231","title":"Antimicrobial Peptide LL-37 Is Both a Substrate of Cathepsins S and K and a Selective Inhibitor of Cathepsin L","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Universiteit van Amsterdam; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft","keywords":"Cathepsin; Chemistry; Biochemistry; Cathepsin L; Cathepsin C; Proteases; Antimicrobial peptides; Cathepsin S; Antimicrobial; Peptide; Cysteine; Cathepsin B; Cathepsin O; Microbiology; Molecular biology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152268,0.0001745693,0.0003304035,0.00003449752,0.00005158965,0.00000982265,0.00008410891,0.0002270189,0.00001944877],"category_scores_gemma":[0.00003840712,0.0001631986,0.00005714124,0.00007762993,0.00067225,0.00005884178,0.00008990325,0.0001478442,0.000003889519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002077347,"about_ca_system_score_gemma":0.0001599695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004253512,"about_ca_topic_score_gemma":0.00001156399,"domain_scores_codex":[0.9992254,0.00002978478,0.0002454047,0.0002628124,0.00002817155,0.0002083934],"domain_scores_gemma":[0.9994745,0.00003789512,0.0001893488,0.0001591693,0.0001014459,0.00003762611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001734387,0.0001084283,0.003304626,0.000118156,0.00009219479,0.000002158539,0.00146353,2.169176e-7,0.9864397,0.00002822678,0.008089717,0.0001795861],"study_design_scores_gemma":[0.0009268706,0.0001092972,0.001026221,0.00009605553,0.00004818628,0.0001498857,0.0008981091,0.000001328335,0.9961494,0.00004554089,0.0003849669,0.000164117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969894,0.001717524,0.000007269758,0.0001045917,0.00007432251,0.00009382021,0.0002359656,0.00001678459,0.0007603187],"genre_scores_gemma":[0.9979807,0.0001271652,0.0002178865,0.00005666771,0.00003285847,0.000002212962,0.00002925882,0.00001424026,0.001539081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009709702,"threshold_uncertainty_score":0.6655045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299151546320462,"score_gpt":0.2223110008855966,"score_spread":0.209319485422392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}