{"id":"W1995061448","doi":"10.1006/clim.2000.4964","title":"The Phosphodiesterase Inhibitors Pentoxifylline and Rolipram Suppress Macrophage Activation and Nitric Oxide Production in Vitro and in Vivo","year":2001,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Diabetes Association","keywords":"Rolipram; Pentoxifylline; Nitric oxide; In vivo; Forskolin; Lipopolysaccharide; Phosphodiesterase; Phosphodiesterase inhibitor; Nitric oxide synthase; Macrophage; Pharmacology; Chemistry; Phosphodiesterase 3; In vitro; Endocrinology; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003663585,0.0005591697,0.0006660764,0.0002885577,0.0002041247,0.0003868348,0.0002971177,0.0004084981,0.0008132104],"category_scores_gemma":[0.0003913368,0.0002395283,0.0002664471,0.0001703696,0.0004795115,0.0002491199,0.00020445,0.001313641,0.0003909934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006415,"about_ca_system_score_gemma":0.0003704412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004110754,"about_ca_topic_score_gemma":0.0007900681,"domain_scores_codex":[0.9996737,0.00008909606,0.00001799471,0.00002030507,0.00005374433,0.0001451032],"domain_scores_gemma":[0.999625,0.00008123094,0.00009830961,0.00005432306,0.00001826328,0.0001228836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00536339,0.0004008846,0.0002621491,0.00004201853,0.00001688568,0.0001417713,0.000027658,0.00008428246,0.9867783,0.0001236686,0.0001704889,0.00658851],"study_design_scores_gemma":[0.0009393916,0.0105146,0.006861599,0.00001219981,0.0000669222,0.0008379323,0.00006586726,0.0009067293,0.9771692,0.0001619254,0.00245217,0.00001144661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916169,0.004278482,0.001597613,0.0003845542,0.0001398017,0.00005237716,0.0001181169,0.0001015198,0.001710608],"genre_scores_gemma":[0.9941759,0.002008395,0.001592813,0.0001554169,0.0001065182,0.00006039281,0.0002937781,0.00001903511,0.001587661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008132104,"threshold_uncertainty_score":0.002720475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329951614154352,"score_gpt":0.2858722013774471,"score_spread":0.2725726852359036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}