{"id":"W1995061448","doi":"10.1006/clim.2000.4964","title":"The Phosphodiesterase Inhibitors Pentoxifylline and Rolipram Suppress Macrophage Activation and Nitric Oxide Production in Vitro and in Vivo","year":2001,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Diabetes Association","keywords":"Rolipram; Pentoxifylline; Nitric oxide; In vivo; Forskolin; Lipopolysaccharide; Phosphodiesterase; Phosphodiesterase inhibitor; Nitric oxide synthase; Macrophage; Pharmacology; Chemistry; Phosphodiesterase 3; In vitro; Endocrinology; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004480258,0.0001211814,0.0001655863,0.00006123547,0.00009872751,0.00002916856,0.00004977774,0.0002275591,0.000002989683],"category_scores_gemma":[0.0004494899,0.00009481938,0.0000238746,0.0001128258,0.0003385329,0.00001718431,0.0001142747,0.0002057337,7.153753e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000138833,"about_ca_system_score_gemma":0.00001763651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000497492,"about_ca_topic_score_gemma":0.0001095211,"domain_scores_codex":[0.9988267,0.0001940818,0.0003900206,0.0003592281,0.00004625757,0.0001836656],"domain_scores_gemma":[0.9995208,0.0001151948,0.0001050815,0.0001809993,0.00003750764,0.00004044989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001982491,0.0001058117,0.05491279,0.000007001091,0.00002484321,0.000005175278,0.00003721955,0.00001105314,0.9209228,0.000006874825,0.0001223076,0.02186159],"study_design_scores_gemma":[0.001757714,0.000134891,0.6292368,0.00001959437,0.00001108371,0.00007017377,0.0001717861,0.0001913139,0.3576465,0.0001237805,0.01048763,0.0001486817],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957454,0.002830449,0.00003090808,0.0008593233,0.0002638523,0.0002319388,0.000001834244,0.000007773525,0.0000284883],"genre_scores_gemma":[0.990822,0.00836225,0.00006271451,0.0001673992,0.0001052283,0.00002480987,0.0000211932,0.000009988965,0.0004244465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.574324,"threshold_uncertainty_score":0.3866622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329951614154352,"score_gpt":0.2858722013774471,"score_spread":0.2725726852359036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}