{"id":"W1995063979","doi":"10.1002/anie.200461327","title":"A Stereodivergent Synthesis of Virantmycin by an Enzyme‐Mediated Diester Desymmetrization and a Highly Hindered Aryl Amination","year":2004,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Desymmetrization; Chemistry; Amination; Aryl; Stereoselectivity; Esterase; Bromide; Intramolecular force; Quinoline; Enantiomer; Enantioselective synthesis; Stereochemistry; Combinatorial chemistry; Enzyme; Organic chemistry; Catalysis; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436553,0.0005061976,0.0002520262,0.0002356035,0.0001853888,0.0002255969,0.0003038111,0.0002817946,0.00135753],"category_scores_gemma":[0.0001013878,0.0002052809,0.0001993178,0.0001911994,0.0001899109,0.0003205341,0.0002620801,0.0004898629,0.0005157957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003348933,"about_ca_system_score_gemma":0.0004981855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004044564,"about_ca_topic_score_gemma":0.0008314719,"domain_scores_codex":[0.9999124,0.00001229865,0.00001058101,0.00002262293,0.00001812467,0.00002392707],"domain_scores_gemma":[0.9999415,0.00000668988,0.00001758023,0.00001079086,0.000006581605,0.0000170012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001027277,0.00003939928,0.00008642579,0.00005172762,0.000005912758,0.0001870848,0.00004413637,0.0005021277,0.9895254,0.001696931,0.00006852992,0.00768956],"study_design_scores_gemma":[0.00003746356,0.0003652884,0.0003885969,0.000004339114,0.00001002156,0.000283847,0.000009630986,0.0004954062,0.9929515,0.0001656522,0.00527837,0.000009844684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489635,0.001690467,0.03232149,0.0001788461,0.00007552228,0.0002090597,0.0008602317,0.0002366753,0.01546425],"genre_scores_gemma":[0.9713045,0.001332888,0.02226605,0.00005877632,0.00001472996,0.00008995149,0.0004599972,0.00004482496,0.004428353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135753,"threshold_uncertainty_score":0.004541397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046721065174281,"score_gpt":0.2241302003235084,"score_spread":0.2136629896717656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}