{"id":"W1995065040","doi":"10.1016/j.jmb.2005.10.022","title":"Three Key Residues Underlie the Differential Affinity of the TGFβ Isoforms for the TGFβ Type II Receptor","year":2005,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Biotechnology Research Institute","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Affinities; Gene isoform; Receptor; Chemistry; Ligand (biochemistry); Stereochemistry; Biochemistry; Binding site; Crystallography; Biophysics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002862795,0.0004290712,0.0005753724,0.0001594518,0.0003416137,0.0006595398,0.0006799971,0.0009921314,0.002649096],"category_scores_gemma":[0.0006874796,0.0002879976,0.0006058173,0.00009397753,0.0005011071,0.0004990829,0.0003944047,0.001440239,0.00111862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005401678,"about_ca_system_score_gemma":0.0004155984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007707403,"about_ca_topic_score_gemma":0.0007407877,"domain_scores_codex":[0.9997464,0.00003484411,0.00002101153,0.00004004559,0.00007806128,0.00007967077],"domain_scores_gemma":[0.9994808,0.0001053036,0.0001394932,0.00004432952,0.00008552583,0.0001444836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005545467,0.00002927393,0.0006181718,0.00006095152,0.00001985532,0.0003647523,0.00005256339,0.0002380323,0.9933344,0.00243228,0.0001134508,0.002181661],"study_design_scores_gemma":[0.00026833,0.0003648068,0.02807209,0.00003109129,0.00007953787,0.003196046,0.0001178087,0.005295117,0.9571719,0.002075269,0.003276163,0.0000517207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797797,0.001518547,0.01460268,0.0006498873,0.0001454217,0.00005733727,0.0002428153,0.0001073322,0.002896354],"genre_scores_gemma":[0.9932653,0.0004865138,0.004152616,0.0002387819,0.0000324372,0.0000318106,0.0001925787,0.00002413968,0.001575826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002649096,"threshold_uncertainty_score":0.008862138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01530637279730433,"score_gpt":0.2766527946702288,"score_spread":0.2613464218729245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}