{"id":"W1995107778","doi":"10.1016/j.bmcl.2008.04.012","title":"Potent triazolyl-proline-based inhibitors of HCV NS3 protease","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Tripeptide; Moiety; Triazole; Sulfonamide; Quinoline; Protease; NS3; Aryl; Combinatorial chemistry; Stereochemistry; Isostere; Sitagliptin; Peptidomimetic; Enzyme; Biochemistry; Peptide; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000235953,0.0004628682,0.0003006814,0.0002671217,0.0001568736,0.0002816332,0.0004055319,0.0002440403,0.00169766],"category_scores_gemma":[0.0001383356,0.0001718751,0.0001887542,0.0002013752,0.0001679883,0.0001886756,0.0002195371,0.0006217426,0.0005990812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003455133,"about_ca_system_score_gemma":0.0002108959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008492314,"about_ca_topic_score_gemma":0.002162004,"domain_scores_codex":[0.9998983,0.00001728283,0.000007856052,0.00001098315,0.0000221634,0.00004333101],"domain_scores_gemma":[0.9999436,0.000009925559,0.0000124026,0.000004673988,0.000008855708,0.00002059607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00105404,0.0001897803,0.0001869991,0.0002142317,0.00003301091,0.0003475231,0.00006102066,0.001394743,0.9745756,0.0006696412,0.001199466,0.02007391],"study_design_scores_gemma":[0.0007864414,0.003018786,0.002252147,0.00002293461,0.00007170536,0.001237685,0.00003287253,0.003347276,0.9756349,0.0001999751,0.01336323,0.00003204196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590678,0.01423534,0.01093423,0.0005008326,0.0002540332,0.0002236556,0.001070285,0.0004910077,0.01322284],"genre_scores_gemma":[0.9831626,0.00600676,0.003233235,0.0002285978,0.00004060893,0.00007940774,0.0008835257,0.0000213949,0.006343898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169766,"threshold_uncertainty_score":0.00567925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854378877177354,"score_gpt":0.2645114725616579,"score_spread":0.2359676837898843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}