{"id":"W1995113829","doi":"10.1016/j.jmb.2011.12.052","title":"Conformational Dynamics of a Membrane Transport Protein Probed by H/D Exchange and Covalent Labeling: The Glycerol Facilitator","year":2012,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Hydrogen–deuterium exchange; Crystallography; Molecular dynamics; Membrane; Protein subunit; Transmembrane protein; Lipid bilayer; Molecule; Biophysics; Mass spectrometry; Computational chemistry; Biochemistry; Chromatography; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820343,0.000151989,0.0001474152,0.0001109052,0.0003731384,0.0004039055,0.0003818171,0.00031119,0.0007542206],"category_scores_gemma":[0.0002505704,0.000140257,0.0001243998,0.0001493148,0.0005578889,0.0003722209,0.0001490994,0.0006165263,0.0001567051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006101141,"about_ca_system_score_gemma":0.0003186332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001885366,"about_ca_topic_score_gemma":0.001600749,"domain_scores_codex":[0.9999503,0.000006115904,0.00000202306,0.00001356831,0.00001118055,0.00001681867],"domain_scores_gemma":[0.9998728,0.00004356446,0.00002481296,0.00001009937,0.00001622504,0.00003255824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000341185,0.00005140377,0.0008724771,0.00002617862,0.00001240002,0.0001066659,0.00007966668,0.0005207512,0.9962431,0.0004792293,0.00007544977,0.00119153],"study_design_scores_gemma":[0.00005283699,0.0001980302,0.007043978,0.000004689191,0.00002175958,0.0001134392,0.0001115932,0.01295417,0.9784834,0.0002063873,0.0007855914,0.00002401616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989254,0.00007102313,0.0006581451,0.00007836273,0.000005881797,0.00000284148,0.00003106193,0.000008881367,0.0002183394],"genre_scores_gemma":[0.9989813,0.000087343,0.0005297562,0.0000230415,0.000003085712,0.00000340174,0.00006412848,0.000008153348,0.000299794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885366,"threshold_uncertainty_score":0.004426718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005280357259744886,"score_gpt":0.2364797747745256,"score_spread":0.2311994175147807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}