{"id":"W1995183079","doi":"10.1074/jbc.m305952200","title":"Constitutive Activation of the Angiotensin II Type 1 Receptor Alters the Spatial Proximity of Transmembrane 7 to the Ligand-binding Pocket","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Receptor; Ligand (biochemistry); Transmembrane domain; Transmembrane protein; Biophysics; Agonist; Binding site; G protein-coupled receptor; Chemistry; Mutant; Cysteine; Angiotensin II; Stereochemistry; Biochemistry; Biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000538308,0.000107378,0.0001858796,0.000008574842,0.0001218018,0.000007334235,0.0002827994,0.0001568508,0.00007865761],"category_scores_gemma":[0.0004776274,0.00004604966,0.0001869443,0.0001195755,0.0001665438,0.00000386681,0.00004780526,0.00019177,3.179938e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001430938,"about_ca_system_score_gemma":0.0001092231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004271218,"about_ca_topic_score_gemma":6.170916e-7,"domain_scores_codex":[0.999162,0.0001020674,0.0003345157,0.0001197255,0.0001551882,0.0001264836],"domain_scores_gemma":[0.9991643,0.00004818896,0.0003576739,0.0001684177,0.0002175314,0.00004384577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002072019,0.00004510886,0.0001972592,0.000008515379,0.00005808968,2.792074e-7,0.00009508104,0.0001173537,0.998561,0.00003347039,0.0002873508,0.0003892428],"study_design_scores_gemma":[0.0002366659,0.0002934092,0.0001407956,0.00004904504,0.00001976419,0.00002423344,0.0002349201,0.000004174367,0.9938138,0.00005660541,0.005063051,0.0000636089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997459,0.000181961,0.001132632,0.0006743687,0.000184937,0.0001359034,0.00001236083,0.000001253154,0.0002176049],"genre_scores_gemma":[0.9991779,0.00006716292,0.0003441268,0.0001764086,0.0001716255,0.000001457909,0.000004745222,0.000004649704,0.0000519545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0047757,"threshold_uncertainty_score":0.1877851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932613962643649,"score_gpt":0.2386483526086014,"score_spread":0.2193222129821649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}