{"id":"W1995200161","doi":"10.1007/s11033-012-1975-3","title":"ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia","year":2012,"lang":"en","type":"article","venue":"Molecular Biology Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; National Institute for Health and Care Research; Natural Sciences and Engineering Research Council of Canada; Cancer Research UK","keywords":"ATF4; Gene knockdown; Autophagy; Hypoxia (environmental); RNA interference; Cell biology; Biology; Cancer research; Mediator; Transcription factor; Small interfering RNA; Transcription (linguistics); RNA; Unfolded protein response; Chemistry; Apoptosis; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002075712,0.0002813997,0.000428935,0.00027764,0.0003816549,0.000351664,0.000210387,0.0002747379,0.001213545],"category_scores_gemma":[0.0001660304,0.0001628862,0.0004122961,0.0001793495,0.0004684424,0.0004150908,0.0004444745,0.0004694121,0.0002217339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005287394,"about_ca_system_score_gemma":0.0002723283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007758706,"about_ca_topic_score_gemma":0.0009837482,"domain_scores_codex":[0.9998392,0.00002170092,0.00001301568,0.00002228879,0.00002503782,0.00007879774],"domain_scores_gemma":[0.9998693,0.00001030762,0.0000294331,0.00001530172,0.00002371342,0.00005185319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009646481,0.00003055776,0.001077158,0.00004173765,0.00001180036,0.0002049413,0.0000476904,0.0001344811,0.994675,0.0006151262,0.0001842941,0.002012498],"study_design_scores_gemma":[0.00004161722,0.000454024,0.08394059,0.00001922661,0.00003499538,0.0007959917,0.0004244825,0.001973391,0.9069742,0.00165359,0.003664604,0.00002326101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913393,0.0011203,0.004440199,0.0003262245,0.00008386486,0.00002619412,0.000436862,0.000121457,0.002105532],"genre_scores_gemma":[0.9963388,0.0003329263,0.0009558062,0.00009881637,0.00002940123,0.00002843188,0.0003756802,0.00002868052,0.001811355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213545,"threshold_uncertainty_score":0.004059732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211331102707647,"score_gpt":0.3162000415066826,"score_spread":0.3040867304796062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}