{"id":"W1995227798","doi":"10.1074/jbc.m110.123216","title":"Human Topoisomerase IIIα Is a Single-stranded DNA Decatenase That Is Stimulated by BLM and RMI1","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Topoisomerase; DNA; Biology; Homologous recombination; Holliday junction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736926,0.0002060213,0.0002621218,0.0000129283,0.00008553617,0.00004439176,0.0002202545,0.000422985,0.0003316876],"category_scores_gemma":[0.00002761025,0.0001506192,0.000163761,0.00004546141,0.0001456837,0.000005238411,0.00007033067,0.0003341675,0.000001071125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001199107,"about_ca_system_score_gemma":0.0000371789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003369484,"about_ca_topic_score_gemma":0.000001842123,"domain_scores_codex":[0.9990135,0.00001711714,0.0003187285,0.0002721287,0.0001356583,0.0002428952],"domain_scores_gemma":[0.9991898,0.00001244076,0.0002449027,0.0002073613,0.0001136755,0.0002318523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001432408,0.0001563759,0.0003836325,0.00001344004,0.00009345767,0.00001490458,0.00002630154,2.73329e-7,0.9959094,0.000003221388,0.001814719,0.001441047],"study_design_scores_gemma":[0.001272812,0.0004826559,0.0001549848,0.00001326217,0.00004120836,0.0001874753,0.00004347256,0.000006025185,0.9724548,0.0004144937,0.02472243,0.0002064157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980979,0.0007944524,0.00008778123,0.0005189092,0.0001014101,0.00006006596,0.00006348576,0.000006879053,0.0002691486],"genre_scores_gemma":[0.9974957,0.0003345012,0.0001776275,0.001261781,0.000275617,0.000002174255,0.00003609744,0.00001452439,0.0004019572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02345463,"threshold_uncertainty_score":0.6142073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02644855750333574,"score_gpt":0.2719761735277423,"score_spread":0.2455276160244065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}