{"id":"W1995256270","doi":"10.1126/science.1126241","title":"Ischemia Opens Neuronal Gap Junction Hemichannels","year":2006,"lang":"en","type":"article","venue":"Science","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":563,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Gap junction; Neuroscience; Ischemia; Pannexin; Biophysics; Connexon; Chemistry; Excitotoxicity; Connexin; Conductance; Cell biology; Intracellular; Biology; Medicine; Internal medicine; Biochemistry; Receptor; NMDA receptor; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001935953,0.00007655005,0.00005537457,0.00003463745,0.0001318519,0.0000265987,0.0002347655,0.00005503323,0.00004433688],"category_scores_gemma":[0.00004319312,0.00006740128,0.0000326517,0.0001593401,0.0003147627,0.000005309944,0.0001293307,0.00004919382,0.00003133377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009599396,"about_ca_system_score_gemma":0.00009937507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003805811,"about_ca_topic_score_gemma":0.00003111233,"domain_scores_codex":[0.9991953,0.00001132795,0.00009290601,0.00035456,0.0001023833,0.0002435286],"domain_scores_gemma":[0.9996317,0.000003647477,0.00003299314,0.0002166063,0.00006947642,0.00004557569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000140636,0.00001390741,0.000916097,0.00000106829,9.500326e-7,7.711324e-7,0.000003508401,0.00002705669,0.995708,0.0002861177,0.00210353,0.0009249371],"study_design_scores_gemma":[0.0001540906,0.0001080548,0.01025353,0.000001865663,0.000002388956,0.000024007,0.00001362442,0.00009208755,0.8442894,0.0002283311,0.1447151,0.0001174907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868151,0.0001516059,0.0005624057,0.0002371564,0.0003260206,0.00005787566,0.00000341596,0.00001096316,0.01183549],"genre_scores_gemma":[0.9968083,0.00001208405,0.0002154095,0.0003686124,0.0003252452,0.000005240239,0.00002175663,0.000004994795,0.002238362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1514186,"threshold_uncertainty_score":0.2748545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004646613575969,"score_gpt":0.2446019923862073,"score_spread":0.2345555262504476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}