{"id":"W1995256270","doi":"10.1126/science.1126241","title":"Ischemia Opens Neuronal Gap Junction Hemichannels","year":2006,"lang":"en","type":"article","venue":"Science","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":563,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Gap junction; Neuroscience; Ischemia; Pannexin; Biophysics; Connexon; Chemistry; Excitotoxicity; Connexin; Conductance; Cell biology; Intracellular; Biology; Medicine; Internal medicine; Biochemistry; Receptor; NMDA receptor; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001246776,0.0002719979,0.0003289437,0.0002012627,0.0002687159,0.0005148918,0.0001781806,0.0003642751,0.0009742652],"category_scores_gemma":[0.000247842,0.0001197057,0.0002111597,0.000151259,0.0003351044,0.0007918872,0.0003765831,0.0005353941,0.0002519183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004744168,"about_ca_system_score_gemma":0.0002570444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003497667,"about_ca_topic_score_gemma":0.0004187106,"domain_scores_codex":[0.9998865,0.00001788964,0.0000120409,0.00002483276,0.00002666436,0.00003198853],"domain_scores_gemma":[0.9998981,0.00003283735,0.00002470492,0.00001462549,0.00001114205,0.00001869551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002136674,0.00002370474,0.0004984056,0.00004715028,0.00000786173,0.0002117585,0.00005219115,0.0001653905,0.9897721,0.001859991,0.0001523893,0.006995263],"study_design_scores_gemma":[0.00003273468,0.0004206472,0.02045277,0.00002888473,0.00003516976,0.001085468,0.0001009207,0.002205314,0.9638286,0.00521605,0.006575059,0.00001833318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809783,0.009101674,0.00538237,0.0003819535,0.0000463592,0.0000194697,0.0001697003,0.0001532083,0.003767071],"genre_scores_gemma":[0.993041,0.004322375,0.001322496,0.0001008404,0.00003004487,0.0000180478,0.0001573512,0.00001029403,0.0009975233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009742652,"threshold_uncertainty_score":0.003442168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004646613575969,"score_gpt":0.2446019923862073,"score_spread":0.2345555262504476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}