{"id":"W1995280708","doi":"10.1074/jbc.275.6.4407","title":"Reversible Inhibition of the Calcium-pumping ATPase in Native Cardiac Sarcoplasmic Reticulum by a Calmodulin-binding Peptide","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Calmodulin; Endoplasmic reticulum; Calcium; ATPase; Calcium ATPase; Peptide; Ryanodine receptor 2; Chemistry; Biophysics; Biochemistry; Internal medicine; Enzyme; Medicine; Ryanodine receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000473694,0.0001537227,0.0004069509,0.00003106014,0.0000941825,0.000007131946,0.0002354064,0.0003775941,0.00111352],"category_scores_gemma":[0.0002066134,0.00009721865,0.0002651396,0.0001829346,0.0002352368,0.00006469716,0.00006410856,0.0007239004,0.00001648574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000125765,"about_ca_system_score_gemma":0.00006283428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002250311,"about_ca_topic_score_gemma":5.428842e-7,"domain_scores_codex":[0.9987381,0.000188458,0.0005750415,0.0001712061,0.00006476993,0.0002624027],"domain_scores_gemma":[0.9992532,0.0001217382,0.0003725225,0.0001511065,0.00007416219,0.00002730301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001758996,0.0001163844,0.001312463,0.00001797413,0.0000540174,0.000008919405,0.00011574,0.00001092227,0.996572,0.00000735341,0.001136096,0.0004722643],"study_design_scores_gemma":[0.0008765605,0.0001458296,0.001217652,0.0002311292,0.00002089661,0.00009100029,0.0004264907,0.000002414517,0.9932688,0.0001203141,0.003480113,0.0001188078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972273,0.001316171,0.00001445527,0.000191478,0.0001857878,0.00009527311,0.00007778683,0.000006726024,0.0008850793],"genre_scores_gemma":[0.998204,0.0003554036,0.00006530963,0.00006546466,0.00003963705,0.000002860976,0.00002030057,0.000006874227,0.001240149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003303174,"threshold_uncertainty_score":0.9997996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313619749566983,"score_gpt":0.2282077931119406,"score_spread":0.2150715956162707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}