{"id":"W1995292245","doi":"10.1074/jbc.m205406200","title":"Trafficking of Cholesterol from Cell Bodies to Distal Axons in Niemann Pick C1-deficient Neurons","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"Fondation pour la Recherche Médicale; Deutsche Forschungsgemeinschaft; University of Alberta","keywords":"NPC1; Cholesterol; Endosome; Niemann–Pick disease, type C; Biology; Cell biology; Niemann–Pick disease; Axoplasmic transport; Neurodegeneration; Cell; Internal medicine; Endocrinology; Chemistry; Biochemistry; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002604268,0.0001414765,0.0004464779,0.00005849502,0.00002800055,0.00001342372,0.000186655,0.000146214,0.0002138027],"category_scores_gemma":[0.0007742012,0.00009752988,0.0001783644,0.000156251,0.0001150433,0.00002990445,0.00005753341,0.0005077707,0.000005866127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009370084,"about_ca_system_score_gemma":0.0000773003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001245291,"about_ca_topic_score_gemma":0.000003848816,"domain_scores_codex":[0.9985754,0.00006209395,0.0005444611,0.000196738,0.0003389582,0.0002823593],"domain_scores_gemma":[0.9991724,0.0001280668,0.0001851705,0.0001639474,0.0001209277,0.0002294445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003647512,0.0009994193,0.1105724,0.00008708169,0.00002639447,0.0002733047,0.0003152657,0.0001276175,0.8863552,0.000002399266,0.0002583837,0.0006178078],"study_design_scores_gemma":[0.00392924,0.001260286,0.2343268,0.0002987732,0.00004427352,0.0002539862,0.001999675,0.00003446645,0.7537624,0.00008273533,0.003738641,0.0002686688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960566,0.0005980913,0.00008050675,0.0003655364,0.00004527155,0.000111932,0.00001514519,0.000006901174,0.002720048],"genre_scores_gemma":[0.9992769,0.00006432793,0.00033681,0.0001215614,0.00006762336,0.000002943577,0.000005190913,0.00000894029,0.000115743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1325927,"threshold_uncertainty_score":0.3977153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03673370304957228,"score_gpt":0.2913695398037957,"score_spread":0.2546358367542234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}