{"id":"W1995311853","doi":"10.1093/jnci/djm140","title":"Response: Re: MLH1 93G>A Promoter Polymorphism and the Risk of Microsatellite-Unstable Colorectal Cancer","year":2007,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Memorial University of Newfoundland; Cancer Care Ontario; Mount Sinai Hospital","funders":"","keywords":"MLH1; Colorectal cancer; Microsatellite instability; Microsatellite; Genetics; Oncology; Medicine; Biology; Cancer research; Internal medicine; Gene; Cancer; DNA mismatch repair; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001435065,0.00132718,0.001473382,0.0009112175,0.001224447,0.001501366,0.002394383,0.01576356,0.08030862],"category_scores_gemma":[0.009984796,0.0004754503,0.001405425,0.000421402,0.001016294,0.00149806,0.001217,0.00955884,0.03971494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002323323,"about_ca_system_score_gemma":0.001603022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005865689,"about_ca_topic_score_gemma":0.004862018,"domain_scores_codex":[0.9990127,0.0002525327,0.000172364,0.0001739699,0.0002301302,0.0001583342],"domain_scores_gemma":[0.9957899,0.001486322,0.0002372823,0.0001298859,0.001639184,0.0007173112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000202671,0.00004234316,0.000902137,0.0001443796,0.00001531025,0.0004038806,0.00002515095,0.00005052795,0.0001130953,0.0001929554,0.9939516,0.003955903],"study_design_scores_gemma":[0.001214834,0.0004104852,0.01462479,0.001391347,0.0001048949,0.002326652,0.0008553072,0.0006233091,0.0008057059,0.002867713,0.9745799,0.0001950529],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001468589,0.001373205,0.0001692918,0.9086679,0.07268462,0.0004567583,0.001537729,0.0003876984,0.01325418],"genre_scores_gemma":[0.008825272,0.001836178,0.000429605,0.8397637,0.07634877,0.0006274399,0.0009095245,0.0001502424,0.07110915],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.08030862,"threshold_uncertainty_score":0.2686591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615307233686796,"score_gpt":0.3172547478467981,"score_spread":0.2911016755099302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}