{"id":"W1995338702","doi":"10.1016/j.cell.2014.04.046","title":"A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":652,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Biology; Acetylation; Histone; Pyruvate dehydrogenase complex; Cell biology; SAP30; Mitochondrion; Biochemistry; Cell nucleus; HDAC4; Histone H2A; Nucleus; DNA; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351376,0.00006387958,0.00007645824,0.00001231162,0.0000789093,0.000006530093,0.00004863959,0.00007586041,0.00005528949],"category_scores_gemma":[0.00002989866,0.00004945193,0.0000438155,0.00002139374,0.00005103174,0.000001579278,0.00002393872,0.00002499541,0.000003555876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003237796,"about_ca_system_score_gemma":0.00001019404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007725719,"about_ca_topic_score_gemma":0.00001511676,"domain_scores_codex":[0.9995632,0.00002850948,0.0001401234,0.0001530261,0.00003695597,0.00007822982],"domain_scores_gemma":[0.9996484,0.00001311636,0.00008839688,0.0001775155,0.00004516833,0.00002743723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005034221,0.00001309995,0.00006557695,0.00001153046,0.000007584671,5.533708e-8,0.0000865363,0.00002162789,0.9883544,0.0001573361,0.01079558,0.0004362623],"study_design_scores_gemma":[0.0004782235,0.0002154222,0.00008889601,9.262832e-7,0.00002024944,0.000002839566,0.00001952351,0.00849989,0.7600775,0.00003609493,0.2305022,0.00005819732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852247,0.0003932467,0.01322098,0.0003274709,0.0002031154,0.000221721,0.00001974645,0.000005338189,0.0003837343],"genre_scores_gemma":[0.9965809,0.00015022,0.001377716,0.0007967373,0.0002690606,0.00001078445,0.0001201714,0.00001229902,0.0006821132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.228277,"threshold_uncertainty_score":0.2016591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02648708404163592,"score_gpt":0.2563228780347747,"score_spread":0.2298357939931387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}