{"id":"W1995346298","doi":"10.1111/j.1365-2958.2009.07020.x","title":"The permease gene<i>nagE2</i>is the key to<i>N</i>‐acetylglucosamine sensing and utilization in<i>Streptomyces coelicolor</i>and is subject to multi‐level control","year":2010,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft","keywords":"Permease; Streptomyces coelicolor; Biology; Actinorhodin; PEP group translocation; Biochemistry; Nutrient sensing; Mutant; Activator (genetics); Phosphoenolpyruvate carboxykinase; Phosphotransferase; Gene; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004825931,0.0002554569,0.0003393837,0.0001041424,0.0002489916,0.00006434651,0.0001479029,0.0001987382,0.00002274033],"category_scores_gemma":[0.0005068418,0.0001463106,0.00006764898,0.0002526791,0.0002643336,0.00002482963,0.0001426243,0.0003522075,0.000020141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002222011,"about_ca_system_score_gemma":0.00004779376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001947259,"about_ca_topic_score_gemma":0.0005756723,"domain_scores_codex":[0.9985061,0.0001516484,0.000303598,0.0005608845,0.0000629484,0.0004147675],"domain_scores_gemma":[0.9990194,0.0001658367,0.00007564308,0.0004398079,0.0001577678,0.0001414892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002192925,0.0000321934,0.0006946467,0.00001674834,0.00005321946,0.00002541726,0.0007393231,7.00034e-7,0.9843609,0.00001603421,0.001471702,0.01236982],"study_design_scores_gemma":[0.001272416,0.0001578178,0.005638488,0.00003230252,0.00008909816,0.0003970846,0.00008127218,0.0001421178,0.9077227,0.0000111111,0.0842519,0.0002037562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621462,0.00137499,0.0004216701,0.03456658,0.0002091782,0.001124255,0.0001105482,0.0000228182,0.00002379857],"genre_scores_gemma":[0.9701751,0.0001585252,0.001644434,0.02766766,0.00008580216,0.000004239957,0.00002360832,0.00002631776,0.0002143578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08278019,"threshold_uncertainty_score":0.5966371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706984581776917,"score_gpt":0.2552708135570375,"score_spread":0.2382009677392684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}