{"id":"W1995351663","doi":"10.1016/j.celrep.2012.08.035","title":"Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance","year":2012,"lang":"en","type":"article","venue":"Cell Reports","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Acetylation; Biology; Candida albicans; Saccharomyces cerevisiae; Hsp90; Cell biology; Lysine; Regulator; Biochemistry; Genetics; Yeast; Heat shock protein; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009579006,0.0002025527,0.0001535082,0.0001051805,0.0001266496,0.0003139165,0.0001934844,0.0001394263,0.0006861289],"category_scores_gemma":[0.00007959297,0.00009244078,0.000140035,0.00008774097,0.0002309106,0.0001348456,0.0001739011,0.0003000935,0.0002741116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074958,"about_ca_system_score_gemma":0.0001875301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004589649,"about_ca_topic_score_gemma":0.0007475669,"domain_scores_codex":[0.9999167,0.0000096568,0.000007087221,0.00001901057,0.00002180251,0.00002579477],"domain_scores_gemma":[0.9999363,0.000004760902,0.00002313626,0.000009005676,0.000008468734,0.00001825674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008248979,0.000007763902,0.0003934351,0.000011811,0.000002702263,0.00002472495,0.000004863977,0.00005234557,0.9975235,0.0001106421,0.00003419653,0.001751484],"study_design_scores_gemma":[0.00002036358,0.0001372066,0.01595649,0.00000298685,0.00001170295,0.0002455119,0.00002648254,0.0006142831,0.9802593,0.0001519213,0.002569074,0.000004758755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927528,0.002925818,0.00213454,0.0001213669,0.00003100036,0.00001218191,0.0002506303,0.0000894919,0.001682299],"genre_scores_gemma":[0.9980547,0.0005639328,0.0006100866,0.0000290973,0.000004677928,0.000004653207,0.0001358982,0.000005529362,0.0005914603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006861289,"threshold_uncertainty_score":0.002295375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006633102506580938,"score_gpt":0.188313705427204,"score_spread":0.1816806029206231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}