{"id":"W1995357525","doi":"10.1021/bi050519d","title":"NmerA, the Metal Binding Domain of Mercuric Ion Reductase, Removes Hg2+ from Proteins, Delivers It to the Catalytic Core, and Protects Cells under Glutathione-Depleted Conditions,","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Mercury impact and mitigation studies","field":"Environmental Science","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources","keywords":"Catalysis; Chemistry; Glutathione; Thioredoxin; Metal; Metal ions in aqueous solution; Thioredoxin reductase; Intracellular; Escherichia coli; Biophysics; Stereochemistry; Biochemistry; Enzyme; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035575,0.0002782546,0.0002453396,0.00003677125,0.0004900052,0.00005125216,0.0003368953,0.0001140508,0.0004307099],"category_scores_gemma":[0.0001326277,0.0001867465,0.00008112731,0.0003789317,0.000544987,0.0001610682,0.0002401292,0.0002190364,0.0002007728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001752517,"about_ca_system_score_gemma":0.00004377467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003234964,"about_ca_topic_score_gemma":0.0000150745,"domain_scores_codex":[0.9982693,0.00008103601,0.0003660993,0.0004540589,0.0004818597,0.0003476254],"domain_scores_gemma":[0.999,0.0001432662,0.0001861232,0.0004791316,0.00002737309,0.0001641173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003582582,0.00006019397,0.0001755389,0.00002675614,0.0000985633,0.000003068983,0.003264284,0.001873483,0.9836716,0.00001777796,0.01018317,0.0005897587],"study_design_scores_gemma":[0.0005492353,0.00005971928,0.0009363533,0.00009023733,0.0001135364,0.00002453581,0.01020917,0.001034868,0.9824323,0.0002798496,0.003922984,0.0003472079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946381,0.0003821939,0.00006643181,0.002668757,0.0000293895,0.0009194307,0.0003337848,0.00003634826,0.0009254917],"genre_scores_gemma":[0.9974285,0.00006276349,0.0009009968,0.0005108019,0.000124376,0.00009394101,0.0001025822,0.00002234599,0.0007536814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006944884,"threshold_uncertainty_score":0.7615301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0165020137854078,"score_gpt":0.2429903166244251,"score_spread":0.2264883028390172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}