{"id":"W1995388616","doi":"10.1074/jbc.m111.295188","title":"Two-component PhoB-PhoR Regulatory System and Ferric Uptake Regulator Sense Phosphate and Iron to Control Virulence Genes in Type III and VI Secretion Systems of Edwardsiella tarda","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity Western University; Western University","funders":"Biomedical Research Council; National University of Singapore","keywords":"Regulon; Biology; Operon; Virulence; Secretion; Microbiology; Type VI secretion system; Response regulator; Transcriptional regulation; Transcription (linguistics); Regulator; Gene; Promoter; Electrophoretic mobility shift assay; Regulation of gene expression; Transcription factor; Escherichia coli; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005638436,0.0001792635,0.0004388502,0.00003698462,0.0000428111,0.00001691524,0.00009864596,0.000186272,0.00000524021],"category_scores_gemma":[0.0001169636,0.0001302736,0.00004895628,0.00006693586,0.0002011736,0.000007091569,0.0001486937,0.0001250714,2.727261e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003817584,"about_ca_system_score_gemma":0.00004115022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003600659,"about_ca_topic_score_gemma":0.000002028922,"domain_scores_codex":[0.9987769,0.0000930739,0.000484173,0.0002773028,0.0001493608,0.0002192445],"domain_scores_gemma":[0.9991611,0.00002768328,0.000281652,0.0001591743,0.0001813801,0.000189047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001361647,0.00003615444,0.008033771,0.0002239975,0.00006061842,0.00003458546,0.00005491858,0.00001190404,0.9896961,0.000007596327,0.00002837415,0.0004502876],"study_design_scores_gemma":[0.002442202,0.0009656677,0.1224116,0.0003392513,0.00004558472,0.0006411246,0.0007814898,0.0001689065,0.8714375,0.00001071296,0.0004815134,0.000274462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857489,0.01383826,0.00003858154,0.00002410865,0.00008615012,0.0001746948,0.00001827009,0.00000427553,0.0000666843],"genre_scores_gemma":[0.9972891,0.002294234,0.0002184201,0.0000190092,0.0001343382,0.000005846249,0.000004319355,0.000008922333,0.00002579199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1182587,"threshold_uncertainty_score":0.5312403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800428680327706,"score_gpt":0.2423844780478183,"score_spread":0.2243801912445413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}