{"id":"W1995389617","doi":"10.1007/s00280-002-0443-5","title":"Analysis of age, estimated creatinine clearance and pretreatment hematologic parameters as predictors of fludarabine toxicity in patients treated for chronic lymphocytic leukemia: a CALGB (9011) coordinated intergroup study","year":2002,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute on Aging","keywords":"Fludarabine; Medicine; Toxicity; Creatinine; Internal medicine; Renal function; Gastroenterology; Chronic lymphocytic leukemia; Anemia; Neutropenia; Clinical endpoint; Interquartile range; Leukemia; Surgery; Cyclophosphamide; Chemotherapy; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829138,0.0002924316,0.001246734,0.0004165463,0.00004278144,0.000006358735,0.0001137181,0.0001778322,0.0004580115],"category_scores_gemma":[0.00005875039,0.0002408682,0.0001164326,0.0009529841,0.0004146278,0.00005255322,0.00004396922,0.0001435322,5.524006e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01112357,"about_ca_system_score_gemma":0.0008504903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002237302,"about_ca_topic_score_gemma":0.0001549393,"domain_scores_codex":[0.9981207,0.0001294644,0.0006307546,0.0005280233,0.00019539,0.0003956398],"domain_scores_gemma":[0.998898,0.0003132604,0.0002569836,0.0002175351,0.0001595652,0.0001546643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0219436,0.003133655,0.913133,0.001682738,0.01350459,0.0001576005,0.005260692,0.003989515,0.02388582,0.0000044554,0.0005750749,0.0127293],"study_design_scores_gemma":[0.1751606,0.01528149,0.204478,0.0003297541,0.004791212,0.00002225296,0.0001658733,0.4578321,0.1415045,0.000009578984,0.00003946117,0.0003852007],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949856,0.002481299,0.00001365291,0.00005326027,0.00006302207,0.002262051,0.00006524308,0.00003356686,0.00004225567],"genre_scores_gemma":[0.996933,0.002188321,0.000061254,0.0001620426,0.00001715751,0.0004001979,0.00004762402,0.00002866415,0.0001617839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.708655,"threshold_uncertainty_score":0.9926726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03070062146814773,"score_gpt":0.3453199439162757,"score_spread":0.314619322448128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}