{"id":"W1995487745","doi":"10.1074/jbc.m114.604603","title":"The Essential Autophagy Gene ATG7 Modulates Organ Fibrosis via Regulation of Endothelial-to-Mesenchymal Transition","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"University of Toronto; Heart and Stroke Foundation of Canada","keywords":"Autophagy; Extracellular matrix; Mesenchymal stem cell; Fibrosis; Fibroblast; Cell biology; Pulmonary fibrosis; Biology; Cancer research; Epithelial–mesenchymal transition; Myofibroblast; Cardiac fibrosis; Pathology; Downregulation and upregulation; Medicine; In vitro; Gene; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129027,0.0001730785,0.0003013406,0.0002409512,0.0001686799,0.0002778711,0.0001378075,0.0002962883,0.0006053849],"category_scores_gemma":[0.0001038864,0.0000910049,0.0002053078,0.000117089,0.0003989333,0.0002133226,0.0001609103,0.000529556,0.0001315769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002205904,"about_ca_system_score_gemma":0.0002169386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002368662,"about_ca_topic_score_gemma":0.0005351665,"domain_scores_codex":[0.9998507,0.0000472706,0.00001346837,0.00001642219,0.00002216856,0.00004995495],"domain_scores_gemma":[0.9999231,0.00001199866,0.00002086597,0.000007009402,0.00001190913,0.00002507158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000517957,0.00007832479,0.0004311728,0.00006040442,0.00001336221,0.00009451396,0.00002029014,0.00006903015,0.9966381,0.0002777925,0.00009237748,0.001706812],"study_design_scores_gemma":[0.00007365719,0.0008541737,0.01373544,0.00001501991,0.00007750034,0.0002363314,0.0001002311,0.001133202,0.9810145,0.0002905372,0.002459043,0.00001028418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950536,0.002438876,0.0009432925,0.000177499,0.00004278537,0.00001601805,0.0001203655,0.0000643782,0.001143162],"genre_scores_gemma":[0.9977846,0.0009543192,0.0003621956,0.00006457989,0.000007455502,0.00001956142,0.00008972257,0.000009854448,0.0007078924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006053849,"threshold_uncertainty_score":0.002025187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008491750018638384,"score_gpt":0.2424337790570999,"score_spread":0.2339420290384615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}