{"id":"W1995493096","doi":"10.1593/neo.06469","title":"Novel RING E3 Ubiquitin Ligases in Breast Cancer","year":2006,"lang":"en","type":"review","venue":"Neoplasia","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; Biology; Breast cancer; Estrogen receptor; Cell biology; Cancer research; Cancer; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006202249,0.0008870406,0.001043977,0.001643456,0.0003234661,0.0006820231,0.0008512959,0.001258861,0.003317656],"category_scores_gemma":[0.0004379946,0.0002920481,0.0002912595,0.001668314,0.0004493943,0.001205138,0.0005639069,0.001332295,0.003972902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008348078,"about_ca_system_score_gemma":0.0006883269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009191314,"about_ca_topic_score_gemma":0.001660928,"domain_scores_codex":[0.9998763,0.00001770464,0.00001396704,0.0000230739,0.0000536794,0.00001542109],"domain_scores_gemma":[0.9998578,0.00003654668,0.00002097657,0.000006191579,0.00004716988,0.00003131273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001127356,0.00008833667,0.000237501,0.003909593,0.00004926796,0.0005443365,0.0000468129,0.0004429911,0.003651365,0.003907849,0.04112422,0.9458849],"study_design_scores_gemma":[0.00002452171,0.00006565605,0.000523817,0.0005030547,0.00003048466,0.00204515,0.00002423034,0.00006150088,0.0007340041,0.001268274,0.9947106,0.000008856005],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002465856,0.996872,0.0003027768,0.0003199862,0.0002511718,0.000008132068,0.00001345188,0.00001627979,0.00196962],"genre_scores_gemma":[0.001220035,0.9952886,0.0004076851,0.0003074872,0.0001725218,0.000009025191,0.00003601136,0.000002313093,0.002556372],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003317656,"threshold_uncertainty_score":0.01109868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02855568729635732,"score_gpt":0.3066180077981993,"score_spread":0.2780623205018419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}