{"id":"W1995493096","doi":"10.1593/neo.06469","title":"Novel RING E3 Ubiquitin Ligases in Breast Cancer","year":2006,"lang":"en","type":"review","venue":"Neoplasia","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; Biology; Breast cancer; Estrogen receptor; Cell biology; Cancer research; Cancer; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001602234,0.0004746153,0.0008354414,0.0001306628,0.00005491839,0.00004449733,0.0003520163,0.0005992312,0.0000861122],"category_scores_gemma":[0.00002235941,0.0004357266,0.0003327793,0.000206556,0.00005310238,0.00000324465,0.0001856446,0.0003453328,0.00004944386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006802215,"about_ca_system_score_gemma":0.0004311317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003236936,"about_ca_topic_score_gemma":0.0005087781,"domain_scores_codex":[0.9981639,0.00007406807,0.0004965613,0.000640066,0.0001538432,0.0004715102],"domain_scores_gemma":[0.9991828,0.00002470544,0.0002334802,0.0004221525,0.00004249508,0.00009439995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001990626,0.0001404191,0.0001672793,0.006095272,0.00008990429,0.00003288051,0.00001878817,0.000007314967,0.003232859,0.00005919117,0.003534016,0.9866022],"study_design_scores_gemma":[0.0003103634,0.00003336614,0.00009618764,0.004276691,0.00009834149,0.0003166907,0.000004148209,0.000002847766,0.00178519,0.000005252159,0.9925908,0.0004801162],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007947953,0.9927023,0.00002294319,0.00002986663,0.0002309974,0.0005066468,0.0008131861,0.00002544035,0.004873835],"genre_scores_gemma":[0.0004856574,0.995943,0.0001677584,0.00009489045,0.001087651,0.0003585537,0.0006208632,0.00009476615,0.001146857],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9890568,"threshold_uncertainty_score":0.9998094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02855568729635732,"score_gpt":0.3066180077981993,"score_spread":0.2780623205018419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}