{"id":"W1995496043","doi":"10.1016/j.cub.2008.07.078","title":"Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation","year":2008,"lang":"en","type":"article","venue":"Current Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":336,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Biology; mTORC1; Phosphorylation; Cell biology; MAPK/ERK pathway; Signal transduction; Genetics; Protein kinase B","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955548,0.0006684064,0.0002446752,0.0004074406,0.0002400507,0.000386309,0.0002317456,0.0002638242,0.002728378],"category_scores_gemma":[0.0002242237,0.000240159,0.000332198,0.0002793952,0.0002808317,0.0003227428,0.0003991026,0.0006742249,0.0009446798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004995391,"about_ca_system_score_gemma":0.0002528813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004208836,"about_ca_topic_score_gemma":0.0007367592,"domain_scores_codex":[0.9998305,0.0000264445,0.00001660905,0.0000301727,0.00003784714,0.00005834601],"domain_scores_gemma":[0.9999065,0.00001854256,0.00002263188,0.00001453795,0.00001037511,0.0000273195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005550248,0.00009452298,0.000470765,0.0001630663,0.00001751077,0.0001505747,0.00002222778,0.0002819395,0.9911246,0.0008775229,0.0005165386,0.0057257],"study_design_scores_gemma":[0.00003488814,0.0001946643,0.003270698,0.000006634236,0.00002296417,0.0003976329,0.00002591201,0.001230869,0.9892384,0.0001711864,0.005399899,0.000006252678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846116,0.003076163,0.003363414,0.0005172103,0.0001201013,0.000037833,0.000904159,0.0005728388,0.00679678],"genre_scores_gemma":[0.9948184,0.001096,0.001499609,0.00007010142,0.00002821244,0.00003707486,0.0006902142,0.000038085,0.001722365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002728378,"threshold_uncertainty_score":0.009127319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02448276231675751,"score_gpt":0.2912210106265944,"score_spread":0.2667382483098369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}